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    RASGRF2 Ras protein specific guanine nucleotide releasing factor 2 [ Gallus gallus (chicken) ]

    Gene ID: 100859132, updated on 3-Apr-2024

    Summary

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    Symbol
    RASGRF2provided by CGNC
    Full Name
    Ras protein specific guanine nucleotide releasing factor 2provided by CGNC
    Primary source
    CGNC:66088
    See related
    Ensembl:ENSGALG00010007166
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See RASGRF2 in Genome Data Viewer
    Location:
    chromosome: Z
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (64500889..64628065, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (64500889..64628065, complement)

    Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene zinc finger CCHC-type containing 9 Neighboring gene creatine kinase, mitochondrial 2 Neighboring gene uncharacterized LOC107052408 Neighboring gene mutS homolog 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ras-specific guanine nucleotide-releasing factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      64500889..64628065 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003643077.6 → XP_003643125.1  ras-specific guanine nucleotide-releasing factor 2 isoform X4

      UniProtKB/TrEMBL
      A0A8V0XMW3
      Conserved Domains (8) summary
      smart00147
      Location:999 → 1235
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:901 → 973
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      smart00233
      Location:479 → 587
      PH; Pleckstrin homology domain
      cd13261
      Location:19 → 157
      PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:24 → 132
      PH; PH domain
      pfam00618
      Location:637 → 686
      RasGEF_N; RasGEF N-terminal motif
      pfam00621
      Location:246 → 427
      RhoGEF; RhoGEF domain
      pfam08418
      Location:725 → 814
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

    2. XM_004949460.5 → XP_004949517.1  ras-specific guanine nucleotide-releasing factor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0XMW3, A0A8V0XU59
      Related
      ENSGALP00010009529.1, ENSGALT00010017091.1
      Conserved Domains (8) summary
      smart00147
      Location:1000 → 1236
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:902 → 974
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      smart00233
      Location:479 → 587
      PH; Pleckstrin homology domain
      cd13261
      Location:19 → 157
      PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:24 → 132
      PH; PH domain
      pfam00618
      Location:637 → 686
      RasGEF_N; RasGEF N-terminal motif
      pfam00621
      Location:246 → 427
      RhoGEF; RhoGEF domain
      pfam08418
      Location:725 → 814
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

    3. XM_015280710.4 → XP_015136196.1  ras-specific guanine nucleotide-releasing factor 2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0XMW3
      Conserved Domains (8) summary
      smart00147
      Location:1033 → 1269
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:935 → 1007
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      smart00233
      Location:513 → 621
      PH; Pleckstrin homology domain
      cd13261
      Location:19 → 157
      PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:24 → 132
      PH; PH domain
      pfam00618
      Location:671 → 720
      RasGEF_N; RasGEF N-terminal motif
      pfam00621
      Location:246 → 461
      RhoGEF; RhoGEF domain
      pfam08418
      Location:759 → 848
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

    4. XM_015280709.4 → XP_015136195.1  ras-specific guanine nucleotide-releasing factor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0XMW3
      Conserved Domains (8) summary
      smart00147
      Location:1034 → 1270
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:936 → 1008
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      smart00233
      Location:513 → 621
      PH; Pleckstrin homology domain
      cd13261
      Location:19 → 157
      PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:24 → 132
      PH; PH domain
      pfam00618
      Location:671 → 720
      RasGEF_N; RasGEF N-terminal motif
      pfam00621
      Location:246 → 461
      RhoGEF; RhoGEF domain
      pfam08418
      Location:759 → 848
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

    5. XM_015280711.4 → XP_015136197.1  ras-specific guanine nucleotide-releasing factor 2 isoform X5

      Conserved Domains (7) summary
      smart00233
      Location:513 → 621
      PH; Pleckstrin homology domain
      cd13261
      Location:19 → 157
      PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:24 → 132
      PH; PH domain
      pfam00618
      Location:671 → 720
      RasGEF_N; RasGEF N-terminal motif
      pfam00621
      Location:246 → 461
      RhoGEF; RhoGEF domain
      pfam08418
      Location:759 → 848
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
      cl02520
      Location:936 → 968
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

    RNA

    1. XR_005843209.2 RNA Sequence

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      64500889..64628065 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046937020.1 → XP_046792976.1  ras-specific guanine nucleotide-releasing factor 2 isoform X4

    2. XM_046937019.1 → XP_046792975.1  ras-specific guanine nucleotide-releasing factor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0XU59

    3. XM_046937018.1 → XP_046792974.1  ras-specific guanine nucleotide-releasing factor 2 isoform X2

    4. XM_046937017.1 → XP_046792973.1  ras-specific guanine nucleotide-releasing factor 2 isoform X1

    5. XM_046937021.1 → XP_046792977.1  ras-specific guanine nucleotide-releasing factor 2 isoform X5

    RNA

    1. XR_006938061.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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