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    Mlh1 mutL homolog 1 [ Cavia porcellus (domestic guinea pig) ]

    Gene ID: 100717848, updated on 8-Mar-2024

    Summary

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    Gene symbol
    Mlh1
    Gene description
    mutL homolog 1
    See related
    Ensembl:ENSCPOG00000003928
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Cavia porcellus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae; Cavia
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: Un
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current mCavPor4.1 (GCF_034190915.1) Unplaced Scaffold NW_026947496.1 (68120019..68181807, complement)
    103 previous assembly Cavpor3.0 (GCF_000151735.1) Unplaced Scaffold NT_176403.1 (37430455..37475886, complement)

    NW_026947496.1Genomic Context describing neighboring genes Neighboring gene golgin A4 Neighboring gene U6 spliceosomal RNA Neighboring gene LRR binding FLII interacting protein 2 Neighboring gene small nucleolar RNA U13 Neighboring gene cyclin-dependent kinase 4-like Neighboring gene EPM2A interacting protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mismatch repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in somatic hypermutation of immunoglobulin genes IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MutLalpha complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA mismatch repair protein Mlh1
    Names
    mutL homolog 1, colon cancer, nonpolyposis type 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_034190915.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mCavPor4.1

    Genomic

    1. NW_026947496.1 Reference mCavPor4.1

      Range
      68120019..68181807 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063260337.1 → XP_063116407.1  DNA mismatch repair protein Mlh1 isoform X2

    2. XM_003473471.5 → XP_003473519.1  DNA mismatch repair protein Mlh1 isoform X1

      UniProtKB/TrEMBL
      H0V205
      Related
      ENSCPOP00000003547.2
      Conserved Domains (4) summary
      cd03483
      Location:211 → 335
      MutL_Trans_MLH1; MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to ...
      TIGR00585
      Location:6 → 315
      mutl; DNA mismatch repair protein MutL
      pfam16413
      Location:503 → 758
      Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus
      cl00075
      Location:31 → 132
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

    3. XM_013156290.3 → XP_013011744.2  DNA mismatch repair protein Mlh1 isoform X3

      Conserved Domains (2) summary
      TIGR00585
      Location:44 → 318
      mutl; DNA mismatch repair protein MutL
      pfam16413
      Location:507 → 723
      Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus

    4. XM_063260339.1 → XP_063116409.1  DNA mismatch repair protein Mlh1 isoform X4

    Nucleotide Protein
    Heading Accession and Version

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