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    ACTN1 actinin alpha 1 [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100341378, updated on 3-Apr-2024

    Summary

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    Gene symbol
    ACTN1
    Gene description
    actinin alpha 1
    See related
    Ensembl:ENSOCUG00000015449
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 20
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 20 NC_067393.1 (2999142..3101665)

    Chromosome 20 - NC_067393.1Genomic Context describing neighboring genes Neighboring gene exonuclease 3'-5' domain containing 2 Neighboring gene uncharacterized LOC127484648 Neighboring gene DDB1 and CUL4 associated factor 5 Neighboring gene uncharacterized LOC103351640 Neighboring gene ZFP36 ring finger protein like 1 Neighboring gene uncharacterized LOC127484609

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_067393.1 Chromosome 20 Reference UM_NZW_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. α-Actinin Promotes Surface Localization and Current Density of the Ca(2+) Channel Ca(V)1.2 by Binding to the IQ Region of the α1 Subunit. Tseng PY, et al. Biochemistry, 2017 Jul 18. PMID 28613835, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in muscle cell development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cortical actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-actinin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UM_NZW_1.0 Primary Assembly

    Genomic

    1. NC_067393.1 Reference UM_NZW_1.0 Primary Assembly

      Range
      2999142..3101665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002719521.4 → XP_002719567.1  alpha-actinin-1 isoform X1

      UniProtKB/TrEMBL
      A0A5F9CPF7
      Related
      ENSOCUP00000035531.1
      Conserved Domains (7) summary
      cd00014
      Location:145 → 249
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00051
      Location:750 → 839
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:395 → 622
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:32 → 130
      CH; Calponin homology (CH) domain
      pfam00435
      Location:634 → 733
      Spectrin; Spectrin repeat
      pfam08726
      Location:844 → 910
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      pfam13499
      Location:752 → 838
      EF-hand_7; EF-hand domain pair

    2. XM_017349364.2 → XP_017204853.1  alpha-actinin-1 isoform X3

      UniProtKB/TrEMBL
      A0A5F9CPF7, A0A5F9DRD6
      Related
      ENSOCUP00000037350.1

    3. XM_017349365.2 → XP_017204854.1  alpha-actinin-1 isoform X4

      UniProtKB/TrEMBL
      A0A5F9DRD6
      Related
      ENSOCUP00000037520.1

    4. XM_051826323.1 → XP_051682283.1  alpha-actinin-1 isoform X5

    5. XM_017349363.2 → XP_017204852.2  alpha-actinin-1 isoform X2

    Nucleotide Protein
    Heading Accession and Version

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