nes nestin [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nesprovided by ZNC
Official Full Name: nestinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-071119-2
See related: Ensembl:ENSDARG00000088805 AllianceGenome:ZFIN:ZDB-GENE-071119-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable intermediate filament binding activity. Involved in brain development; embryonic camera-type eye development; and negative regulation of apoptotic process. Acts upstream of or within cranial nerve development. Predicted to be located in intermediate filament. Is expressed in several structures, including adaxial cell; gut epithelium; nervous system; neural crest cell; and neuronal stem cell. Orthologous to human NES (nestin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (29043631..29053655)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (29109049..29118689)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Morphine increases GFP in nestin:GFP embryos and overexpresses the NSC marker Nestin. Morphine also exerts a hyperacetylation effect on H3K27 and decreases DNA methylation in a region 18 Kb upstream of the nestin transcription starting site. A binding site for the transcription factor complex Sox2/Oct4/Nanog was predicted.
Title: Morphine delays neural stem cells differentiation by facilitating Nestin overexpression.
Nestin gene may serve as a marker for stem cells and proliferating precursors in the developing embryonic nervous system as well as in the postembryonic brain[Nestin]
Title: Expression of the zebrafish intermediate neurofilament Nestin in the developing nervous system and in neural proliferation zones at postembryonic stages.
Results suggest that nestin is essential for brain and eye development probably through control of progenitor cell apoptosis.
Title: Nestin is essential for zebrafish brain and eye development through control of progenitor cell apoptosis.
Cells expressing the two reporters display radial glial morphology, colocalize with the NSC marker Sox2, undergo proliferation, and are capable of self-renewal within the matrix of distinct thickness in the telencephalon.
Title: gfap and nestin reporter lines reveal characteristics of neural progenitors in the adult zebrafish brain.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables intermediate filament binding	IEA Inferred from Electronic Annotation more info
enables intermediate filament binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cranial nerve development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of intermediate filament depolymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neural precursor cell proliferation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in intermediate filament	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nestin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001424069.1 → NP_001410998.1 nestin

Status: VALIDATED

Source sequence(s)

CR848841

UniProtKB/Swiss-Prot

P86839

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

29043631..29053655

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001919887.7 → XP_001919922.1 nestin

UniProtKB/Swiss-Prot

P86839

Related

ENSDARP00000112046.1, ENSDART00000122681.3

Conserved Domains (1) summary

pfam00038
Location:16 → 323

Filament; Intermediate filament protein