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    FAS Fas cell surface death receptor [ Equus caballus (horse) ]

    Gene ID: 100071639, updated on 8-Mar-2024

    Summary

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    Official Symbol
    FASprovided by VGNC
    Official Full Name
    Fas cell surface death receptorprovided by VGNC
    Primary source
    VGNC:VGNC:17916
    See related
    Ensembl:ENSECAG00000013724
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See FAS in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    103 current EquCab3.0 (GCF_002863925.1) 1 NC_009144.3 (39638243..39662484, complement)
    102 previous assembly EquCab2.0 (GCF_000002305.2) 1 NC_009144.2 (39302193..39316522, complement)

    Chromosome 1 - NC_009144.3Genomic Context describing neighboring genes Neighboring gene cholesterol 25-hydroxylase Neighboring gene uncharacterized LOC102147963 Neighboring gene uncharacterized LOC111773917 Neighboring gene STAM binding protein like 1 Neighboring gene actin alpha 2, smooth muscle Neighboring gene ankyrin repeat domain 22 Neighboring gene lipase family member M

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Is FAS/Fas ligand system involved in equine corpus luteum functional regression? Galvao AM, et al. Biol Reprod, 2010 Dec. PMID 20720169
    2. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. demonstration of presence of FAS and FASL in the equine corpus luteum throughout the luteal phase
      Title: Is FAS/Fas ligand system involved in equine corpus luteum functional regression?
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables tumor necrosis factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation-induced cell death of T cells IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in motor neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in necroptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of stress-activated MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CD95 death-inducing signaling complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tumor necrosis factor receptor superfamily member 6
    Names
    Fas (TNF receptor superfamily, member 6)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Equus caballus Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009144.3 Reference EquCab3.0 Primary Assembly

      Range
      39638243..39662484 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023643111.1 → XP_023498879.1  tumor necrosis factor receptor superfamily member 6 isoform X3

      UniProtKB/TrEMBL
      A0A9L0THI2, F6ZZH9
      Related
      ENSECAP00000086613.1, ENSECAT00000101781.1
      Conserved Domains (2) summary
      cd08316
      Location:224 → 315
      Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
      cd10579
      Location:40 → 168
      TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)

    2. XM_014733084.2 → XP_014588570.1  tumor necrosis factor receptor superfamily member 6 isoform X2

      UniProtKB/TrEMBL
      F6ZZH9
      Conserved Domains (2) summary
      cd08316
      Location:244 → 335
      Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
      cd10579
      Location:58 → 188
      TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)

    3. XM_014733083.2 → XP_014588569.1  tumor necrosis factor receptor superfamily member 6 isoform X1

      UniProtKB/TrEMBL
      A0A9L0TB11, F6ZZH9
      Related
      ENSECAP00000083770.1, ENSECAT00000121510.1
      Conserved Domains (2) summary
      cd08316
      Location:254 → 345
      Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
      cd10579
      Location:70 → 198
      TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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