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    PTPRU protein tyrosine phosphatase receptor type U [ Equus caballus (horse) ]

    Gene ID: 100070588, updated on 8-Mar-2024

    Summary

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    Official Symbol
    PTPRUprovided by VGNC
    Official Full Name
    protein tyrosine phosphatase receptor type Uprovided by VGNC
    Primary source
    VGNC:VGNC:58645
    See related
    Ensembl:ENSECAG00000012344
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    103 current EquCab3.0 (GCF_002863925.1) 2 NC_009145.3 (26994411..27073363, complement)
    102 previous assembly EquCab2.0 (GCF_000002305.2) 2 NC_009145.2 (26923873..27002526, complement)

    Chromosome 2 - NC_009145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111771915 Neighboring gene uncharacterized LOC111771927 Neighboring gene U6 spliceosomal RNA Neighboring gene mitochondrial trans-2-enoyl-CoA reductase Neighboring gene serine and arginine rich splicing factor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    receptor-type tyrosine-protein phosphatase U

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Equus caballus Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009145.3 Reference EquCab3.0 Primary Assembly

      Range
      26994411..27073363 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023634826.1 → XP_023490594.1  receptor-type tyrosine-protein phosphatase U isoform X3

      UniProtKB/TrEMBL
      F6RES3
      Related
      ENSECAP00000010129.4, ENSECAT00000012816.4
      Conserved Domains (5) summary
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00047
      Location:1195 → 1428
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:386 → 481
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:494 → 577
      fn3; Fibronectin type III domain
      pfam00102
      Location:908 → 1133
      Y_phosphatase; Protein-tyrosine phosphatase

    2. XM_023634822.1 → XP_023490590.1  receptor-type tyrosine-protein phosphatase U isoform X2

      UniProtKB/TrEMBL
      F6RES3
      Conserved Domains (5) summary
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00047
      Location:1202 → 1435
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:386 → 481
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:494 → 577
      fn3; Fibronectin type III domain
      pfam00102
      Location:918 → 1140
      Y_phosphatase; Protein-tyrosine phosphatase

    3. XM_023634818.1 → XP_023490586.1  receptor-type tyrosine-protein phosphatase U isoform X1

      UniProtKB/TrEMBL
      F6RES3
      Related
      ENSECAP00000024121.3, ENSECAT00000051200.3
      Conserved Domains (5) summary
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00047
      Location:1205 → 1438
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:386 → 481
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:494 → 577
      fn3; Fibronectin type III domain
      pfam00102
      Location:918 → 1143
      Y_phosphatase; Protein-tyrosine phosphatase

    4. XM_023634831.1 → XP_023490599.1  receptor-type tyrosine-protein phosphatase U isoform X4

      UniProtKB/TrEMBL
      F6RES3
      Conserved Domains (5) summary
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00047
      Location:1192 → 1425
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:386 → 481
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:494 → 577
      fn3; Fibronectin type III domain
      pfam00102
      Location:908 → 1130
      Y_phosphatase; Protein-tyrosine phosphatase
    Nucleotide Protein
    Heading Accession and Version

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