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    SMG6 SMG6 nonsense mediated mRNA decay factor [ Equus caballus (horse) ]

    Gene ID: 100060172, updated on 8-Mar-2024

    Summary

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    Official Symbol
    SMG6provided by VGNC
    Official Full Name
    SMG6 nonsense mediated mRNA decay factorprovided by VGNC
    Primary source
    VGNC:VGNC:23339
    See related
    Ensembl:ENSECAG00000006519
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 11
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    103 current EquCab3.0 (GCF_002863925.1) 11 NC_009154.3 (45971037..46183956, complement)
    102 previous assembly EquCab2.0 (GCF_000002305.2) 11 NC_009154.2 (45649602..45864197, complement)

    Chromosome 11 - NC_009154.3Genomic Context describing neighboring genes Neighboring gene microRNA mir-212 Neighboring gene HIC ZBTB transcriptional repressor 1 Neighboring gene uncharacterized LOC111775715 Neighboring gene U6 spliceosomal RNA Neighboring gene small nucleolar RNA SNORD91 family Neighboring gene small nucleolar RNA SNORD91 family Neighboring gene serine racemase Neighboring gene TSR1 ribosome maturation factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables telomerase RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables telomeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of telomerase holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    telomerase-binding protein EST1A
    Names
    smg-6 homolog, nonsense mediated mRNA decay factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Equus caballus Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009154.3 Reference EquCab3.0 Primary Assembly

      Range
      45971037..46183956 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005597656.3 → XP_005597713.1  telomerase-binding protein EST1A isoform X1

      See identical proteins and their annotated locations for XP_005597713.1

      UniProtKB/TrEMBL
      A0A9L0R1D4, F6VUE8
      Related
      ENSECAP00000057888.1, ENSECAT00000113965.1
      Conserved Domains (4) summary
      cd09885
      Location:1233 → 1408
      PIN_Smg6; PIN domain of human telomerase-binding protein EST1, Smg6, and other similar eukaryotic homologs
      sd00006
      Location:757 → 787
      TPR; TPR repeat [structural motif]
      pfam10373
      Location:743 → 1095
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:630 → 733
      EST1; Telomerase activating protein Est1

    2. XM_014727907.2 → XP_014583393.2  telomerase-binding protein EST1A isoform X3

      Conserved Domains (1) summary
      cd09885
      Location:245 → 420
      PIN_Smg6; PIN domain of human telomerase-binding protein EST1, Smg6, and other similar eukaryotic homologs

    3. XM_001504355.5 → XP_001504405.1  telomerase-binding protein EST1A isoform X2

      See identical proteins and their annotated locations for XP_001504405.1

      UniProtKB/TrEMBL
      A0A9L0SZY7, F6VUE8
      Related
      ENSECAP00000080509.1, ENSECAT00000142796.1
      Conserved Domains (4) summary
      cd09885
      Location:1232 → 1407
      PIN_Smg6; PIN domain of human telomerase-binding protein EST1, Smg6, and other similar eukaryotic homologs
      sd00006
      Location:756 → 786
      TPR; TPR repeat [structural motif]
      pfam10373
      Location:742 → 1094
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:629 → 732
      EST1; Telomerase activating protein Est1

    RNA

    1. XR_288064.3 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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