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    GCLC glutamate-cysteine ligase catalytic subunit [ Equus caballus (horse) ]

    Gene ID: 100056731, updated on 8-Mar-2024

    Summary

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    Official Symbol
    GCLCprovided by VGNC
    Official Full Name
    glutamate-cysteine ligase catalytic subunitprovided by VGNC
    Primary source
    VGNC:VGNC:18277
    See related
    Ensembl:ENSECAG00000017346
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 20
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    103 current EquCab3.0 (GCF_002863925.1) 20 NC_009163.3 (52095016..52139519, complement)
    102 previous assembly EquCab2.0 (GCF_000002305.2) 20 NC_009163.2 (50986167..51029212, complement)

    Chromosome 20 - NC_009163.3Genomic Context describing neighboring genes Neighboring gene ELOVL fatty acid elongase 5 Neighboring gene uncharacterized LOC106782268 Neighboring gene uncharacterized LOC111769349 Neighboring gene uncharacterized LOC111769350

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables glutamate-cysteine ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of glutamate-cysteine ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutamate--cysteine ligase catalytic subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Equus caballus Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009163.3 Reference EquCab3.0 Primary Assembly

      Range
      52095016..52139519 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_014734500.2 → XP_014589986.1  glutamate--cysteine ligase catalytic subunit isoform X2

      UniProtKB/TrEMBL
      A0A9L0RP17, F6RB82
      Related
      ENSECAP00000063568.1, ENSECAT00000118680.1
      Conserved Domains (2) summary
      pfam03074
      Location:236 → 569
      GCS; Glutamate-cysteine ligase
      cl09927
      Location:25 → 67
      S1_like; S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain. ...

    2. XM_001503180.6 → XP_001503230.2  glutamate--cysteine ligase catalytic subunit isoform X1

      UniProtKB/TrEMBL
      F6RB82
      Related
      ENSECAP00000015436.2, ENSECAT00000018896.3
      Conserved Domains (2) summary
      pfam03074
      Location:236 → 608
      GCS; Glutamate-cysteine ligase
      cl09927
      Location:25 → 67
      S1_like; S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain. ...
    Nucleotide Protein
    Heading Accession and Version

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