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    NBR1 NBR1 autophagy cargo receptor [ Equus caballus (horse) ]

    Gene ID: 100051928, updated on 8-Mar-2024

    Summary

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    Official Symbol
    NBR1provided by VGNC
    Official Full Name
    NBR1 autophagy cargo receptorprovided by VGNC
    Primary source
    VGNC:VGNC:20571
    See related
    Ensembl:ENSECAG00000006950
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 11
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    103 current EquCab3.0 (GCF_002863925.1) 11 NC_009154.3 (20092159..20120944, complement)
    102 previous assembly EquCab2.0 (GCF_000002305.2) 11 NC_009154.2 (20022749..20051445, complement)

    Chromosome 11 - NC_009154.3Genomic Context describing neighboring genes Neighboring gene putative uncharacterized protein DDB_G0294196 Neighboring gene transmembrane protein 106A Neighboring gene BRCA1 DNA repair associated Neighboring gene uncharacterized LOC111775632 Neighboring gene Rho family GTPase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in macroautophagy IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in phagophore assembly site IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    next to BRCA1 gene 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Equus caballus Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009154.3 Reference EquCab3.0 Primary Assembly

      Range
      20092159..20120944 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003362546.4 → XP_003362594.2  next to BRCA1 gene 1 protein isoform X1

      UniProtKB/TrEMBL
      A0A3Q2HS82, A0A3Q2I2C9
      Related
      ENSECAP00000032833.2, ENSECAT00000055117.2
      Conserved Domains (5) summary
      cd06396
      Location:5 → 85
      PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
      cd02340
      Location:215 → 259
      ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
      cd14319
      Location:935 → 973
      UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
      pfam16158
      Location:379 → 478
      N_BRCA1_IG; Ig-like domain from next to BRCA1 gene
      cl26733
      Location:283 → 325
      Peptidase_S49_N; Peptidase family S49 N-terminal

    2. XM_005597361.3 → XP_005597418.2  next to BRCA1 gene 1 protein isoform X2

      UniProtKB/TrEMBL
      A0A3Q2I2C9
      Conserved Domains (5) summary
      cd06396
      Location:5 → 85
      PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
      cd02340
      Location:214 → 258
      ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
      cd14319
      Location:934 → 972
      UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
      pfam16158
      Location:378 → 477
      N_BRCA1_IG; Ig-like domain from next to BRCA1 gene
      cl26733
      Location:282 → 324
      Peptidase_S49_N; Peptidase family S49 N-terminal

    3. XM_014739979.2 → XP_014595465.1  next to BRCA1 gene 1 protein isoform X3

      UniProtKB/TrEMBL
      A0A3Q2H8U4, A0A3Q2I2C9
      Related
      ENSECAP00000030372.1, ENSECAT00000044114.2
      Conserved Domains (4) summary
      cd06396
      Location:5 → 85
      PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
      cd02340
      Location:215 → 259
      ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
      cd14319
      Location:898 → 936
      UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
      cd14947
      Location:369 → 479
      NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins

    4. XM_005597360.3 → XP_005597417.2  next to BRCA1 gene 1 protein isoform X1

      UniProtKB/TrEMBL
      A0A3Q2HS82, A0A3Q2I2C9
      Related
      ENSECAP00000037995.1, ENSECAT00000056448.2
      Conserved Domains (5) summary
      cd06396
      Location:5 → 85
      PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
      cd02340
      Location:215 → 259
      ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
      cd14319
      Location:935 → 973
      UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
      pfam16158
      Location:379 → 478
      N_BRCA1_IG; Ig-like domain from next to BRCA1 gene
      cl26733
      Location:283 → 325
      Peptidase_S49_N; Peptidase family S49 N-terminal

    RNA

    1. XR_288013.3 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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