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    CLCN5 chloride voltage-gated channel 5 [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100008741, updated on 8-Mar-2024

    Summary

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    Gene symbol
    CLCN5
    Gene description
    chloride voltage-gated channel 5
    See related
    Ensembl:ENSOCUG00000017336
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Also known as
    CLCN4
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: X
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) X NC_067395.1 (34130073..34306750)

    Chromosome X - NC_067395.1Genomic Context describing neighboring genes Neighboring gene claudin domain-containing protein 1-like Neighboring gene ubiquitin specific peptidase 27 X-linked Neighboring gene U6 spliceosomal RNA Neighboring gene microRNA mir-502b Neighboring gene microRNA mir-532 Neighboring gene microRNA mir-188 Neighboring gene microRNA mir-502a Neighboring gene microRNA mir-500 Neighboring gene microRNA mir-362 Neighboring gene microRNA mir-501 Neighboring gene microRNA mir-660 Neighboring gene uncharacterized LOC127484854 Neighboring gene uncharacterized LOC103351833

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_067395.1 Chromosome X Reference UM_NZW_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables voltage-gated chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chloride transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    H(+)/Cl(-) exchange transporter 5
    Names
    chloride channel 5 (nephrolithiasis 2, X-linked, Dent disease)
    chloride channel CLC-5
    chloride channel protein 5
    chloride channel, voltage-sensitive 5
    chloride transporter ClC-5
    clC-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082068.1 → NP_001075537.1  H(+)/Cl(-) exchange transporter 5

      See identical proteins and their annotated locations for NP_001075537.1

      Status: PROVISIONAL

      Source sequence(s)
      AF195523
      UniProtKB/Swiss-Prot
      Q9TTU3
      Conserved Domains (4) summary
      COG0517
      Location:583 → 729
      CBS; CBS domain [Signal transduction mechanisms]
      cd03684
      Location:65 → 570
      ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...
      cd04591
      Location:595 → 731
      CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
      pfam00654
      Location:149 → 550
      Voltage_CLC; Voltage gated chloride channel

    RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UM_NZW_1.0 Primary Assembly

    Genomic

    1. NC_067395.1 Reference UM_NZW_1.0 Primary Assembly

      Range
      34130073..34306750
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008272337.3 → XP_008270559.1  H(+)/Cl(-) exchange transporter 5 isoform X1

      UniProtKB/Swiss-Prot
      G1TDH8, Q9TTU3
      Related
      ENSOCUP00000014899.2
      Conserved Domains (2) summary
      cd03684
      Location:135 → 640
      ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...
      cd04591
      Location:651 → 801
      CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria

    2. XM_008272338.3 → XP_008270560.1  H(+)/Cl(-) exchange transporter 5 isoform X2

      See identical proteins and their annotated locations for XP_008270560.1

      UniProtKB/Swiss-Prot
      Q9TTU3
      Conserved Domains (4) summary
      COG0517
      Location:583 → 729
      CBS; CBS domain [Signal transduction mechanisms]
      cd03684
      Location:65 → 570
      ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...
      cd04591
      Location:595 → 731
      CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
      pfam00654
      Location:149 → 550
      Voltage_CLC; Voltage gated chloride channel

    3. XM_008272339.3 → XP_008270561.1  H(+)/Cl(-) exchange transporter 5 isoform X2

      See identical proteins and their annotated locations for XP_008270561.1

      UniProtKB/Swiss-Prot
      Q9TTU3
      Conserved Domains (4) summary
      COG0517
      Location:583 → 729
      CBS; CBS domain [Signal transduction mechanisms]
      cd03684
      Location:65 → 570
      ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...
      cd04591
      Location:595 → 731
      CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
      pfam00654
      Location:149 → 550
      Voltage_CLC; Voltage gated chloride channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TTU3.2 GenPept UniProtKB/Swiss-Prot:Q9TTU3

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