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    dok2 docking protein 2 [ Danio rerio (zebrafish) ]

    Gene ID: 100001537, updated on 11-Apr-2024

    Summary

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    Official Symbol
    dok2provided by ZNC
    Official Full Name
    docking protein 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080721-4
    See related
    Ensembl:ENSDARG00000075818 AllianceGenome:ZFIN:ZDB-GENE-080721-4
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Acts upstream of or within primitive erythrocyte differentiation. Predicted to be active in cytoplasm. Orthologous to human DOK2 (docking protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 8
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (42548474..42594472, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (42541687..42587668, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:ch211-158d24.4 Neighboring gene GDNF family receptor alpha 2a Neighboring gene Kazal-type serine peptidase inhibitor domain 3 Neighboring gene crystallin, beta B2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Purification of zebrafish erythrocytes as a means of identifying a novel regulator of haematopoiesis. Kulkeaw K, et al. Br J Haematol, 2018 Feb. PMID 29265183, Free PMC Article
    2. Comparative genomics of Lbx loci reveals conservation of identical Lbx ohnologs in bony vertebrates. Wotton KR, et al. BMC Evol Biol, 2008 Jun 9. PMID 18541024, Free PMC Article
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within primitive erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    docking protein 2; docking protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      42548474..42594472 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001341478.8 → XP_001341514.7  docking protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M1PZH7
      Related
      ENSDARP00000120631.1, ENSDART00000135238.3
      Conserved Domains (2) summary
      cd01203
      Location:183 → 280
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cd14676
      Location:34 → 146
      PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394739.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      298353..302886 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021472132.1 → XP_021327807.1  docking protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PA01
      Conserved Domains (1) summary
      cd01203
      Location:31 → 128
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    Nucleotide Protein Strain
    Heading Accession and Version

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