FCGR2A Fc gamma receptor IIa [Homo sapiens (human)] - Gene

Summary

Official Symbol: FCGR2Aprovided by HGNC
Official Full Name: Fc gamma receptor IIaprovided by HGNC
Primary source: HGNC:HGNC:3616
See related: Ensembl:ENSG00000143226 MIM:146790; AllianceGenome:HGNC:3616
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD32; FCG2; FcGR; CD32A; CDw32; FCGR2; IGFR2; FCGR2A1; FcgammaRIIa
Summary: This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
Expression: Broad expression in appendix (RPKM 39.7), placenta (RPKM 36.5) and 21 other tissues See more
Orthologs: all
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Genomic context

Location:: 1q23.3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (161505457..161524048)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (160768080..160786676)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (161475247..161489619)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulatory mechanism of FCGR2A in macrophage polarization and its effects on intervertebral disc degeneration.
Title: Regulatory mechanism of FCGR2A in macrophage polarization and its effects on intervertebral disc degeneration.
Genetic variation of FcgammaRIIa induces higher uptake of Leishmania infantum and modulates cytokine production by adherent mononuclear cells in vitro.
Title: Genetic variation of FcγRIIa induces higher uptake of Leishmania infantum and modulates cytokine production by adherent mononuclear cells in vitro.
New candidate SNPs for genetic association with Alzheimer's disease: a linkage disequilibrium analysis for the FCGRIIB and PILRA genes.
Title: New candidate SNPs for genetic association with Alzheimer's disease: a linkage disequilibrium analysis for the FCGRIIB and PILRA genes.
Platelet FcgammaRIIa expression in patients with stable coronary artery disease.
Title: Platelet FcγRIIa expression in patients with stable coronary artery disease.
Relationship Between Human FCgammaRIIA rs1801274 G Allele and Risk of Death Among Different SARS-CoV-2 Variants.
Title: Relationship Between Human FCγRIIA rs1801274 G Allele and Risk of Death Among Different SARS-CoV-2 Variants.
Association between functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to rituximab in patients with autoimmune diseases: a meta-analysis.
Title: Association between functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to rituximab in patients with autoimmune diseases: a meta-analysis.
Association between the functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to biologics in rheumatoid arthritis patients: A meta-analysis.
Title: Association between the functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to biologics in rheumatoid arthritis patients: A meta-analysis.
Comparative Analysis of FCGR Gene Polymorphism in Pulmonary Sarcoidosis and Tuberculosis.
Title: Comparative Analysis of FCGR Gene Polymorphism in Pulmonary Sarcoidosis and Tuberculosis.
Systematic identification of genomic elements that regulate FCGR2A expression and harbor variants linked with autoimmune disease.
Title: Systematic identification of genomic elements that regulate FCGR2A expression and harbor variants linked with autoimmune disease.
Cytoskeleton Dependent Mobility Dynamics of FcgammaRIIA Facilitates Platelet Haptotaxis and Capture of Opsonized Bacteria.
Title: Cytoskeleton Dependent Mobility Dynamics of FcγRIIA Facilitates Platelet Haptotaxis and Capture of Opsonized Bacteria.

Submit: New GeneRIF Correction See all GeneRIFs (352)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Cystic fibrosis MedGen: C0010674 OMIM: 219700 GeneReviews: Cystic Fibrosis	Compare labs
Malaria, susceptibility to MedGen: C1970028 OMIM: 611162 GeneReviews: Not available	Compare labs
Systemic lupus erythematosus MedGen: C0024141 OMIM: 152700 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetics of rheumatoid arthritis contributes to biology and drug discovery. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association identifies multiple ulcerative colitis susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies multiple loci influencing human serum metabolite levels. EBI GWAS Catalog EBI GWAS CatalogPubMed
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region. EBI GWAS Catalog EBI GWAS CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of genetic loci associated with Helicobacter pylori serologic status. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	IgG2 and IgG4 bind more poorly to enzymatically deglycosylated recombinant gp120 (rgp120) than to unchanged rgp120	PubMed
Nef	nef	HIV-1 Nef downregulates Fc-gamma Receptor II in human monocytes/macrophages	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1S3418 (e-PCR)
- UniSTS:53553

D8S2279 (e-PCR)
- UniSTS:473907

AL009695 (e-PCR)
- UniSTS:34374

RH68292 (e-PCR)
- UniSTS:55115

GDB:190031 (e-PCR)
- UniSTS:155610

RH17750 (e-PCR)
- UniSTS:38381

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables IgG binding	IBA Inferred from Biological aspect of Ancestor more info
enables IgG receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Fc-gamma receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in antibody-dependent cellular cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of tumor necrosis factor production	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in secretory granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: low affinity immunoglobulin gamma Fc region receptor II-a

Names: Fc fragment of IgG receptor IIa; Fc fragment of IgG, low affinity IIa, receptor (CD32); Fc gamma receptor RIIa3; Immunoglobulin G Fc receptor II; fc-gamma-RIIa; fcRII-a; igG Fc receptor II-a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012066.2 RefSeqGene

Range

5043..19415

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1109

mRNA and Protein(s)

NM_001136219.3 → NP_001129691.1 low affinity immunoglobulin gamma Fc region receptor II-a isoform 1 precursor

See identical proteins and their annotated locations for NP_001129691.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AA634082, AK315225, AL590385

Consensus CDS

CCDS44264.1

UniProtKB/Swiss-Prot

P12318, Q8WUN1, Q8WW64

UniProtKB/TrEMBL

A0A346JF56

Related

ENSP00000271450.6, ENST00000271450.12

Conserved Domains (3) summary

cd05752
Location:41 → 119

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:123 → 205

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

smart00410
Location:129 → 205

IG_like; Immunoglobulin like
NM_001375296.1 → NP_001362225.1 low affinity immunoglobulin gamma Fc region receptor II-a isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AL590385, BC019931, BX379627

Consensus CDS

CCDS91088.1

UniProtKB/TrEMBL

A0A346JF56, A0A8V8TPS4

Related

ENSP00000514258.1, ENST00000699277.1

Conserved Domains (2) summary

cd05752
Location:41 → 119

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:123 → 205

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
NM_001375297.1 → NP_001362226.1 low affinity immunoglobulin gamma Fc region receptor II-a isoform 4 precursor

Status: REVIEWED

Source sequence(s)

AL590385

UniProtKB/TrEMBL

A0A346JF56

Conserved Domains (2) summary

cd05752
Location:40 → 118

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:122 → 204

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
NM_021642.5 → NP_067674.2 low affinity immunoglobulin gamma Fc region receptor II-a isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AL590385, BC019931

Consensus CDS

CCDS30922.1

UniProtKB/TrEMBL

A0A346JF56

Related

ENSP00000356949.4, ENST00000367972.8

Conserved Domains (3) summary

cd05752
Location:40 → 118

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:122 → 204

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

smart00410
Location:128 → 204

IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

161505457..161524048

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017000664.2 → XP_016856153.1 low affinity immunoglobulin gamma Fc region receptor II-a isoform X3

UniProtKB/TrEMBL

A0A346JF56
XM_017000665.2 → XP_016856154.1 low affinity immunoglobulin gamma Fc region receptor II-a isoform X3

UniProtKB/TrEMBL

A0A346JF56
XM_017000666.2 → XP_016856155.1 low affinity immunoglobulin gamma Fc region receptor II-a isoform X4

UniProtKB/TrEMBL

A0A346JF56

Conserved Domains (3) summary

cd05752
Location:41 → 119

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:123 → 205

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

smart00410
Location:129 → 205

IG_like; Immunoglobulin like
XM_047449441.1 → XP_047305397.1 low affinity immunoglobulin gamma Fc region receptor II-a isoform X1
XM_017000663.3 → XP_016856152.1 low affinity immunoglobulin gamma Fc region receptor II-a isoform X2

UniProtKB/TrEMBL

A0A346JF56

Conserved Domains (3) summary

cd05752
Location:40 → 118

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:122 → 204

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

smart00410
Location:128 → 204

IG_like; Immunoglobulin like
XM_011509290.3 → XP_011507592.1 low affinity immunoglobulin gamma Fc region receptor II-a isoform X5

UniProtKB/TrEMBL

A0A346JF56

Conserved Domains (3) summary

cd05752
Location:41 → 119

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:123 → 205

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

smart00410
Location:129 → 205

IG_like; Immunoglobulin like
XM_011509291.2 → XP_011507593.1 low affinity immunoglobulin gamma Fc region receptor II-a isoform X6

Conserved Domains (3) summary

cd05752
Location:41 → 119

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:123 → 205

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

smart00410
Location:129 → 205

IG_like; Immunoglobulin like
XM_024454040.2 → XP_024309808.1 low affinity immunoglobulin gamma Fc region receptor II-a isoform X7

Conserved Domains (1) summary

cd05753
Location:1 → 66

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

160768080..160786676

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054335134.1 → XP_054191109.1 low affinity immunoglobulin gamma Fc region receptor II-a isoform X3
XM_054335135.1 → XP_054191110.1 low affinity immunoglobulin gamma Fc region receptor II-a isoform X3
XM_054335136.1 → XP_054191111.1 low affinity immunoglobulin gamma Fc region receptor II-a isoform X4
XM_054335132.1 → XP_054191107.1 low affinity immunoglobulin gamma Fc region receptor II-a isoform X1
XM_054335133.1 → XP_054191108.1 low affinity immunoglobulin gamma Fc region receptor II-a isoform X2
XM_054335137.1 → XP_054191112.1 low affinity immunoglobulin gamma Fc region receptor II-a isoform X5
XM_054335138.1 → XP_054191113.1 low affinity immunoglobulin gamma Fc region receptor II-a isoform X7