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    Ppap2b phosphatidic acid phosphatase type 2B [ Mus musculus (house mouse) ]

    Gene ID: 67916, updated on 26-Jun-2015
    Official Symbol
    Ppap2bprovided by MGI
    Official Full Name
    phosphatidic acid phosphatase type 2Bprovided by MGI
    Primary source
    MGI:MGI:1915166
    See related
    Ensembl:ENSMUSG00000028517; Vega:OTTMUSG00000008128
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lpp3; Ppab2b; AV025606; D4Bwg0538e; D4Bwg1535e; 1110003O22Rik; 2610002D05Rik
    Orthologs
    See Ppap2b in Epigenomics, MapViewer
    Location:
    4 C6; 4 49.18 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 4 NC_000070.6 (105157347..105232767)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (104829952..104905372)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 36893 Neighboring gene predicted gene, 29838 Neighboring gene predicted gene, 40217 Neighboring gene predicted gene 12722

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    integrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphatidate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    sphingosine-1-phosphate phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    Bergmann glial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    canonical Wnt signaling pathway involved in positive regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gastrulation with mouth forming second IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    homotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein stabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of sphingolipid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    single organismal cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    lipid phosphate phosphohydrolase 3
    Names
    lipid phosphate phosphohydrolase 3
    PAP-2b
    PAP2-beta
    PAP2b
    phosphatidate phosphohydrolase type 2b
    phosphatidic acid phosphatase 2b
    NP_542122.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080555.2NP_542122.1  lipid phosphate phosphohydrolase 3

      See identical proteins and their annotated locations for NP_542122.1

      Status: VALIDATED

      Source sequence(s)
      AK159136, AK160056, AV018880, BY129827
      Consensus CDS
      CCDS18417.1
      UniProtKB/Swiss-Prot
      Q99JY8
      Related
      ENSMUSP00000065719, OTTMUSP00000008487, ENSMUST00000064139, OTTMUST00000018472
      Conserved Domains (2) summary
      COG0671
      Location:189274
      PgpB; Membrane-associated phospholipid phosphatase [Lipid metabolism]
      cd03384
      Location:126272
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p3 C57BL/6J

      Range
      105157347..105232767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000026.1 Alternate Mm_Celera

      Range
      103508199..103583768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)