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    CSNK2B casein kinase 2 beta [ Homo sapiens (human) ]

    Gene ID: 1460, updated on 17-Apr-2016
    Official Symbol
    CSNK2Bprovided by HGNC
    Official Full Name
    casein kinase 2 betaprovided by HGNC
    Primary source
    HGNC:HGNC:2460
    See related
    Ensembl:ENSG00000204435 HPRD:00278; MIM:115441; Vega:OTTHUMG00000177888
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G5A; CK2B; CK2N; CSK2B
    Summary
    This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
    Orthologs
    Location:
    6p21.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (31665880..31670070)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (31632995..31637844)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene BCL2 associated athanogene 6 Neighboring gene apolipoprotein M Neighboring gene chromosome 6 open reading frame 47 Neighboring gene G-patch domain and ankyrin repeats 1 Neighboring gene lymphocyte antigen 6 complex, locus G5B Neighboring gene lymphocyte antigen 6 complex, locus G5C

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Common variants associated with general and MMR vaccine-related febrile seizures.
    NHGRI GWA Catalog
    Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, casein kinase 2 beta polypeptide (CSNK2B), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with CSNK2B is decreased by RRE PubMed
    rev Rev activates CK2, an effect hypothesized to promote HIV-1 replication PubMed
    rev phosphorylation of Rev is dependent on the beta subunit of CK2 PubMed
    rev amino acids 35-50 of Rev are involved with electrostatic interactions with CK2 while amino acids 12-24 of Rev are involved with hydrophobic interactions PubMed
    rev CK2 phosphorylates Rev on Serine 5 and Serine 8 PubMed
    rev CK2 modulates the interaction of Rev with nucleolar phosphoprotein B23 by phosphorylating B23 PubMed
    Vpu vpu Phosphorylation of HIV-1 Vpu by casein kinase 2 is required for Vpu-mediated degradation of CD4, regulation of HIV-1 envelope secretion and control of syncytium formation PubMed
    vpu The presence of the casein kinase II phosphorylation sites of HIV-1 Vpu enhances CD4(+) T cell loss in a non-human primate model for HIV-1 infection PubMed
    vpu The HIV-1 Vpu protein is phosphorylated by casein kinase 2 on serine amino acids 52 and 56 PubMed
    matrix gag CK2 has been shown to phosphorylate HIV-1 Matrix in vitro PubMed
    retropepsin gag-pol Purified recombinant HIV-1 protease (rPR) is phosphorylated by casein kinase II, and the activity of rPR is stimulated approximately 2.9-fold as a result of this phosphorylation PubMed
    reverse transcriptase gag-pol Casein kinase II phosphorylates HIV-1 RT p66 and p51 in human cells PubMed
    gag-pol Phosphorylation of HIV-1 RT p66 and p51 by Casein kinase II mediates the stimulation of RNA-dependent DNA polymerase (RDDP) activity in vitro PubMed

    Go to the HIV-1, Human Interaction Database

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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Potential readthrough

    Included gene: LY6G5B

    Homology

    Clone Names

    • MGC138222, MGC138224

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase regulator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    contributes_to protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with PcG protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase CK2 complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Preferred Names
    casein kinase II subunit beta
    Names
    CK II beta
    CSNK2B-LY6G5B-1072
    CSNK2B-LY6G5B-1103
    CSNK2B-LY6G5B-532
    CSNK2B-LY6G5B-560
    CSNK2B-LY6G5B-562
    Casein kinase II beta subunit
    alternative name: G5a, phosvitin
    casein kinase 2, beta polypeptide
    casein kinase II b subunit splicing isoform 132
    casein kinase II b subunit splicing isoform 247
    casein kinase II b subunit splicing isoform 318
    casein kinase II b subunit splicing isoform 660
    casein kinase II b subunit splicing isoform 806
    chimera CSNK2B-LY6G5B splicing isoform 1072
    chimera CSNK2B-LY6G5B splicing isoform 1103
    chimera CSNK2B-LY6G5B splicing isoform 532
    chimera CSNK2B-LY6G5B splicing isoform 560
    chimera CSNK2B-LY6G5B splicing isoform 562
    phosvitin
    protein G5a
    NP_001269314.1
    NP_001311.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282385.1NP_001269314.1  casein kinase II subunit beta isoform 2

      See identical proteins and their annotated locations for NP_001269314.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 3' coding sequence compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL662899, BC112017, BQ643177, DB570461
      UniProtKB/Swiss-Prot
      P67870
      Conserved Domains (1) summary
      smart01085
      Location:8188
      CK_II_beta; Casein kinase II regulatory subunit
    2. NM_001320.6NP_001311.3  casein kinase II subunit beta isoform 1

      See identical proteins and their annotated locations for NP_001311.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL662899, BC112017, DB570461
      Consensus CDS
      CCDS4712.1
      UniProtKB/Swiss-Prot
      P67870
      UniProtKB/TrEMBL
      N0E4C7
      Related
      ENSP00000365042, OTTHUMP00000029060, ENST00000375882, OTTHUMT00000076063
      Conserved Domains (1) summary
      smart01085
      Location:8191
      CK_II_beta; Casein kinase II regulatory subunit

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

      Range
      31665880..31670070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p2 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p2 ALT_REF_LOCI_2

      Range
      3143171..3147361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p2 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.2 Reference GRCh38.p2 ALT_REF_LOCI_3

      Range
      2913651..2917842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p2 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.2 Reference GRCh38.p2 ALT_REF_LOCI_4

      Range
      2970927..2975117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p2 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.2 Reference GRCh38.p2 ALT_REF_LOCI_5

      Range
      3007752..3011942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p2 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.2 Reference GRCh38.p2 ALT_REF_LOCI_6

      Range
      2921704..2925894
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p2 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.2 Reference GRCh38.p2 ALT_REF_LOCI_7

      Range
      2965164..2969354
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      31635793..31639983
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)