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    ARP1 actin-related protein 1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856530, updated on 13-Apr-2024

    Summary

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    Gene symbol
    ARP1
    Gene description
    actin-related protein 1
    Primary source
    SGD:S000001171
    Locus tag
    YHR129C
    See related
    AllianceGenome:SGD:S000001171
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ACT5
    Summary
    A structural constituent of cytoskeleton. Involved in establishment of mitotic spindle orientation; mitotic spindle orientation checkpoint signaling; and nuclear migration. Part of dynactin complex. Orthologous to several human genes including ACTR1B (actin related protein 1B). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ARP1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (362999..364153, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uracil phosphoribosyltransferase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ACT3: a putative centractin homologue in S. cerevisiae is required for proper orientation of the mitotic spindle. Clark SW, et al. J Cell Biol, 1994 Oct. PMID 7929558, Free PMC Article
    2. Cloning and identification of Arp1, an actin-related protein from Pneumocystis carinii. Christopher LJ, et al. J Eukaryot Microbiol, 1995 Mar-Apr. PMID 7757056
    3. Molecular dissection of ARP1 regions required for nuclear migration and cell wall integrity checkpoint functions in Saccharomyces cerevisiae. Igarashi R, et al. Cell Struct Funct, 2005. PMID 16415535
    4. A yeast actin-related protein homologous to that in vertebrate dynactin complex is important for spindle orientation and nuclear migration. Muhua L, et al. Cell, 1994 Aug 26. PMID 8069915
    5. Regulation of the processivity and intracellular localization of Saccharomyces cerevisiae dynein by dynactin. Kardon JR, et al. Proc Natl Acad Sci U S A, 2009 Apr 7. PMID 19293377, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in establishment of mitotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle orientation checkpoint signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dynactin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynactin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular non-membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    actin-related protein 1
    NP_011997.1
    • Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      362999..364153 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179259.1 → NP_011997.1  TPA: actin-related protein 1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011997.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL78, P38696, Q6B1J6
      UniProtKB/TrEMBL
      A0A6A5PXG2, B3LSP3, B5VK62, C7GR73, C8Z9S2, G2WFK2, N1P2U0
      Conserved Domains (1) summary
      smart00268
      Location:12 → 384
      ACTIN; Actin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38696.1

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