PMR1 Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: PMR1
Gene description: Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1
Primary source: SGD:S000003135
Locus tag: YGL167C
See related: AllianceGenome:SGD:S000003135
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: BSD1; LDB1; SSC1
Summary: Enables P-type calcium transporter activity; P-type manganese transporter activity; and calcium ion binding activity. Involved in cellular metal ion homeostasis; macroautophagy; and metal ion transport. Located in Golgi membrane. Used to study Hailey-Hailey disease. Human ortholog(s) of this gene implicated in Hailey-Hailey disease. Orthologous to several human genes including ATP2C1 (ATPase secretory pathway Ca2+ transporting 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (187616..190468, complement)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The pH-sensing Rim101 pathway positively regulates the transcriptional expression of the calcium pump gene PMR1 to affect calcium sensitivity in budding yeast.
Title: The pH-sensing Rim101 pathway positively regulates the transcriptional expression of the calcium pump gene PMR1 to affect calcium sensitivity in budding yeast.
PMR1 promotes interviral recombination between plant, insect, and fungal RNA viruses.
Title: Interviral Recombination between Plant, Insect, and Fungal RNA Viruses: Role of the Intracellular Ca(2+)/Mn(2+) Pump.
Data show that calcium stimulates endoplasmic reticulum and late endosome/trans- to cis-Golgi manganese delivery and bypasses the need for Ca(2+)/Mn(2+)-transporting P-type ATPase Pmr1.
Title: Manganese redistribution by calcium-stimulated vesicle trafficking bypasses the need for P-type ATPase function.
Pmr1p has a central role in cell survival in a Cd2+-rich environment.
Title: The Pmr1 protein, the major yeast Ca2+-ATPase in the Golgi, regulates intracellular levels of the cadmium ion.
PMR1 functions involved drug resistance and Golgi apparatus
Title: A phenomics approach in yeast links proton and calcium pump function in the Golgi.
Results establish that Pmr1-dependent Ca2+ and/or Mn2+ ion homeostasis is necessary for TOR signaling.
Title: Pmr1, a Golgi Ca2+/Mn2+-ATPase, is a regulator of the target of rapamycin (TOR) signaling pathway in yeast.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled monoatomic cation transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type calcium transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables P-type calcium transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables P-type calcium transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type calcium transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables P-type ion transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type manganese transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables inorganic cation transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inorganic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular calcium ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular manganese ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular manganese ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in manganese ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in manganese ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in manganese ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in metal ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1

NP_011348.1

EC 7.2.2.10

High affinity Ca2+/Mn2+ P-type ATPase; required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting, processing; D53A mutant (Mn2+ transporting) is rapamycin sensitive, Q783A mutant (Ca2+ transporting) is rapamycin resistant; Mn2+ transport into Golgi lumen required for rapamycin sensitivity; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease; human ATP2C1 can complement yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

187616..190468 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181032.1 → NP_011348.1 TPA: Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011348.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTY5, P13586

UniProtKB/TrEMBL

A0A8H4C005, A6ZU19, B3LHL9, C7GPP0, C8Z884, N1P4N3

Conserved Domains (1) summary

TIGR01522
Location:35 → 940

ATPase-IIA2_Ca; golgi membrane calcium-translocating P-type ATPase