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    RTT103 Rtt103p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851884, updated on 3-Mar-2024

    Summary

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    Gene symbol
    RTT103
    Gene description
    Rtt103p
    Primary source
    SGD:S000002697
    Locus tag
    YDR289C
    See related
    AllianceGenome:SGD:S000002697
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA polymerase II complex binding activity. Involved in mRNA 3'-end processing and negative regulation of transposition, RNA-mediated. Located in chromatin and site of double-strand break. Orthologous to several human genes including RPRD1A (regulation of nuclear pre-mRNA domain containing 1A) and RPRD1B (regulation of nuclear pre-mRNA domain containing 1B). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1038280..1039509, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene inositol monophosphate 1-phosphatase INM2 Neighboring gene Smc5-Smc6 complex subunit NSE3 Neighboring gene ATP-dependent 3'-5' DNA helicase Neighboring gene Signal recognition particle receptor subunit alpha

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Treatment of Surface Plasmon Resonance (SPR) Background in Total Internal Reflection Ellipsometry: Characterization of RNA Polymerase II Film Formation. Hemzal D, et al. Appl Spectrosc, 2019 Mar. PMID 30784293
    2. Structure and dynamics of the RNAPII CTDsome with Rtt103. Jasnovidova O, et al. Proc Natl Acad Sci U S A, 2017 Oct 17. PMID 29073019, Free PMC Article
    3. Structural insight into recognition of phosphorylated threonine-4 of RNA polymerase II C-terminal domain by Rtt103p. Jasnovidova O, et al. EMBO Rep, 2017 Jun. PMID 28468956, Free PMC Article
    4. Transcription termination complex, Rtt103-Rai1-Rat1, regulates sub-telomeric transcripts in Saccharomyces cerevisiae. Ramalingam K, et al. RNA Biol, 2023 Jan. PMID 36974034, Free PMC Article
    5. Evidence that dissociation of Spt16 from transcribed genes is partially dependent on RNA Polymerase II termination. Campbell JB, et al. Transcription, 2019 Aug-Oct. PMID 31809228, Free PMC Article

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II C-terminal domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II C-terminal domain phosphoserine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II C-terminal domain phosphoserine binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA 3'-end processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrotransposon silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rtt103p
    NP_010575.1
    • Protein implicated in transcription termination by RNA polymerase II; binds to the RNA polymerase II C-terminal domain (CTD) phosphorylated on serine (ser2); interacts with 5' to 3' exonuclease Rat1p and decapping endonuclease Rai1p and is involved in mRNA 3' end processing; contains an RPR domain (CTD-interacting domain); involved in regulation of Ty1 transposition

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1038280..1039509 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180597.1 → NP_010575.1  TPA: Rtt103p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010575.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSR9, Q05543
      UniProtKB/TrEMBL
      A0A8H8UNJ1, A6ZYN8, B3LG05, B5VGG5, C7GQU0, C8Z5K1, N1P560
      Conserved Domains (1) summary
      cd17003
      Location:5 → 131
      CID_Rtt103; CID (CTD-Interacting Domain) of yeast transcription termination factor Rtt103 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05543.1

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