ZIP4 Clathrin adaptor complexes medium subunit family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: ZIP4
Gene description: Clathrin adaptor complexes medium subunit family protein
Primary source: Araport:AT1G56590
Locus tag: AT1G56590
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: adaptor protein-3 mu-adaptin; AP3M; F25P12.96; F25P12_96; ZIG SUPPRESSOR 4
Summary: Involved in vesicle trafficking between the trans -Golgi network and vacuoles.
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Genomic context

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See ZIP4 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 8

Sequence:: Chromosome: 1; NC_003070.9 (21201948..21204856, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A role for AP-3 in pollen tube growth.
Title: The ADAPTOR PROTEIN-3 Complex Mediates Pollen Tube Growth by Coordinating Vacuolar Targeting and Organization.
At1g56590(AP-3micro) positively regulates the abscisic acid responses independently of AGB1 in seed germination, while AP-3micro does require AGB1 to regulate abscisic acid responses during post-germination growth.
Title: The Arabidopsis adaptor protein AP-3μ interacts with the G-protein β subunit AGB1 and is involved in abscisic acid regulation of germination and post-germination development.
zip4 is a loss-of-function mutant of a putative ortholog of the yeast AP-3 mu subunit, and is involved in protein trafficking between the trans-Golgi network and vacuoles.
Title: ZIP genes encode proteins involved in membrane trafficking of the TGN-PVC/vacuoles.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_104536.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within gravitropism	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein targeting to vacuole	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of clathrin adaptor complex	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Clathrin adaptor complexes medium subunit family protein

NP_176052.3

ZIG SUPPRESSOR 4 (ZIP4); INVOLVED IN: intracellular protein transport, gravitropism, protein targeting to vacuole; LOCATED IN: clathrin vesicle coat, clathrin adaptor complex; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Clathrin adaptor, mu subunit, conserved site (InterPro:IPR018240), Clathrin adaptor, mu subunit (InterPro:IPR001392), Clathrin adaptor, mu subunit, C-terminal (InterPro:IPR008968), Longin-like (InterPro:IPR011012); BEST Arabidopsis thaliana protein match is: Clathrin adaptor complexes medium subunit family protein (TAIR:AT1G60780.1); Has 1984 Blast hits to 1954 proteins in 323 species: Archae - 0; Bacteria - 0; Metazoa - 926; Fungi - 482; Plants - 226; Viruses - 0; Other Eukaryotes - 350 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

21201948..21204856 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_104536.5 → NP_176052.3 Clathrin adaptor complexes medium subunit family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_176052.3

Status: REVIEWED

UniProtKB/Swiss-Prot

F4I562, Q9FXB1

UniProtKB/TrEMBL

A0A5S9WQ97, A0A654EP65

Conserved Domains (2) summary

cd09252
Location:167 → 414

AP-3_Mu3_Cterm; C-terminal domain of medium Mu3 subunit in adaptor protein (AP) complex AP-3

cd14837
Location:3 → 142

AP3_Mu_N; AP-3 complex subunit mu N-terminal domain