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    UBC4 ubiquitin conjugating enzyme 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834136, updated on 15-Oct-2023

    Summary

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    Gene symbol
    UBC4
    Gene description
    ubiquitin conjugating enzyme 4
    Primary source
    Araport:AT5G41340
    Locus tag
    AT5G41340
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATUBC4; MYC6.5; MYC6_5; ubiquitin conjugating enzyme 4; UBIQUITIN CONJUGATING ENZYME 4
    Summary
    Belongs to Ubiquitin conjugating enzyme family. Gene expression is developmentally regulated.
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (16538063..16540189, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene stress response NST1-like protein Neighboring gene ncRNA Neighboring gene BTB/POZ domain with WD40/YVTN repeat-like protein Neighboring gene RING/U-box superfamily protein Neighboring gene homolog of Xeroderma pigmentosum complementation group B 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Members of two gene families encoding ubiquitin-conjugating enzymes, AtUBC1-3 and AtUBC4-6, from Arabidopsis thaliana are differentially expressed. Thoma S, et al. Plant Mol Biol, 1996 Jun. PMID 8790283
    2. Homologues of wheat ubiquitin-conjugating enzymes--TaUBC1 and TaUBC4 are encoded by small multigene families in Arabidopsis thaliana. Sullivan ML, et al. Plant Mol Biol, 1994 Feb. PMID 8155884
    3. Arabidopsis Ubiquitin-Conjugating Enzymes UBC4, UBC5, and UBC6 Have Major Functions in Sugar Metabolism and Leaf Senescence. Wang S, et al. Int J Mol Sci, 2022 Sep 22. PMID 36232444, Free PMC Article
    4. Effect of Arabidopsis COP10 ubiquitin E2 enhancement activity across E2 families and functional conservation among its canonical homologues. Lau OS, et al. Biochem J, 2009 Mar 15. PMID 19061479
    5. Genome analysis and functional characterization of the E2 and RING-type E3 ligase ubiquitination enzymes of Arabidopsis. Kraft E, et al. Plant Physiol, 2005 Dec. PMID 16339806, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis Ubiquitin-Conjugating Enzymes UBC4, UBC5, and UBC6 Have Major Functions in Sugar Metabolism and Leaf Senescence.
      Title: Arabidopsis Ubiquitin-Conjugating Enzymes UBC4, UBC5, and UBC6 Have Major Functions in Sugar Metabolism and Leaf Senescence.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001344399.1
    NM_123499.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in response to heat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin conjugating enzyme 4
    NP_568589.1
    • ubiquitin conjugating enzyme 4 (UBC4); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608), Ubiquitin-conjugating enzyme (InterPro:IPR015581); BEST Arabidopsis thaliana protein match is: ubiquitin-conjugating enzyme 5 (TAIR:AT1G63800.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      16538063..16540189 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123499.5 → NP_568589.1  ubiquitin conjugating enzyme 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568589.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P42748, Q4TZ05, Q9FN66
      UniProtKB/TrEMBL
      A0A5S9YAA3, A0A654G6Z0
      Conserved Domains (1) summary
      pfam00179
      Location:7 → 143
      UQ_con; Ubiquitin-conjugating enzyme

    2. NM_001344399.1 → NP_001331159.1  ubiquitin conjugating enzyme 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BD13
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42748.2

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