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    AKR4C8 NAD(P)-linked oxidoreductase superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818353, updated on 11-Apr-2024

    Summary

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    Gene symbol
    AKR4C8
    Gene description
    NAD(P)-linked oxidoreductase superfamily protein
    Primary source
    Araport:AT2G37760
    Locus tag
    AT2G37760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Aldo-keto reductase family 4 member C8; T8P21.6
    Summary
    Encodes an NADPH-dependent aldo-keto reductase that can act on a wide variety of substrates in vitro including aliphatic and aromatic aldehydes and steroids. Transcript levels for this gene are up-regulated in response to cold, salt, and drought stress.
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    8
    Sequence:
    Chromosome: 2; NC_003071.7 (15831656..15833921)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene zinc-finger protein 10 Neighboring gene uncharacterized protein Neighboring gene NAD(P)-linked oxidoreductase superfamily protein Neighboring gene Cysteine/Histidine-rich C1 domain family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of two novel aldo-keto reductases from Arabidopsis: expression patterns, broad substrate specificity, and an open active-site structure suggest a role in toxicant metabolism following stress. Simpson PJ, et al. J Mol Biol, 2009 Sep 18. PMID 19616008
    2. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    3. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001084550.1
    NM_001124993.1
    NM_001336674.1
    NM_129332.5
    NM_201897.4
    NM_201898.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NADP+ binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aldo-keto reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables steroid dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to salt stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 

    General protein information

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    Preferred Names
    NAD(P)-linked oxidoreductase superfamily protein
    NP_001078019.1
    • NAD(P)-linked oxidoreductase superfamily protein; FUNCTIONS IN: oxidoreductase activity; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Aldo/keto reductase (InterPro:IPR001395), Aldo/keto reductase subgroup (InterPro:IPR020471), Aldo/keto reductase, conserved site (InterPro:IPR018170); BEST Arabidopsis thaliana protein match is: NAD(P)-linked oxidoreductase superfamily protein (TAIR:AT2G37770.2); Has 25660 Blast hits to 25635 proteins in 2483 species: Archae - 410; Bacteria - 17272; Metazoa - 2121; Fungi - 1835; Plants - 1211; Viruses - 0; Other Eukaryotes - 2811 (source: NCBI BLink).
    NP_001118465.1
    • NAD(P)-linked oxidoreductase superfamily protein; FUNCTIONS IN: oxidoreductase activity; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Aldo/keto reductase (InterPro:IPR001395), Aldo/keto reductase subgroup (InterPro:IPR020471), Aldo/keto reductase, conserved site (InterPro:IPR018170); BEST Arabidopsis thaliana protein match is: NAD(P)-linked oxidoreductase superfamily protein (TAIR:AT2G37770.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_565871.1
    • NAD(P)-linked oxidoreductase superfamily protein; FUNCTIONS IN: oxidoreductase activity; INVOLVED IN: response to cadmium ion; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Aldo/keto reductase (InterPro:IPR001395), Aldo/keto reductase subgroup (InterPro:IPR020471), Aldo/keto reductase, conserved site (InterPro:IPR018170); BEST Arabidopsis thaliana protein match is: NAD(P)-linked oxidoreductase superfamily protein (TAIR:AT2G37790.1); Has 25671 Blast hits to 25646 proteins in 2485 species: Archae - 414; Bacteria - 17274; Metazoa - 2121; Fungi - 1833; Plants - 1216; Viruses - 0; Other Eukaryotes - 2813 (source: NCBI BLink).
    NP_973626.2
    • NAD(P)-linked oxidoreductase superfamily protein; FUNCTIONS IN: oxidoreductase activity; INVOLVED IN: response to cadmium ion; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Aldo/keto reductase (InterPro:IPR001395), Aldo/keto reductase subgroup (InterPro:IPR020471), Aldo/keto reductase, conserved site (InterPro:IPR018170); BEST Arabidopsis thaliana protein match is: NAD(P)-linked oxidoreductase superfamily protein (TAIR:AT2G37790.1); Has 25671 Blast hits to 25646 proteins in 2485 species: Archae - 414; Bacteria - 17274; Metazoa - 2121; Fungi - 1833; Plants - 1216; Viruses - 0; Other Eukaryotes - 2813 (source: NCBI BLink).
    NP_973627.1
    • NAD(P)-linked oxidoreductase superfamily protein; FUNCTIONS IN: oxidoreductase activity; INVOLVED IN: response to cadmium ion; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Aldo/keto reductase (InterPro:IPR001395), Aldo/keto reductase subgroup (InterPro:IPR020471), Aldo/keto reductase, conserved site (InterPro:IPR018170); BEST Arabidopsis thaliana protein match is: NAD(P)-linked oxidoreductase superfamily protein (TAIR:AT2G37770.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      15831656..15833921
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001336673.1 → NP_001324984.1  NAD(P)-linked oxidoreductase superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B1V1, A0A654FAD5

    2. NM_129332.5 → NP_565871.1  NAD(P)-linked oxidoreductase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565871.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3H474, O80944, Q3E6N6, Q3EBK9, Q93YR4
      UniProtKB/TrEMBL
      A0A178VZ90, A0A5S9X4W0, A0A654FAD5
      Conserved Domains (1) summary
      cd19125
      Location:6 → 288
      AKR_AKR4C1-15; AKR4C family of aldo-keto reductase (AKR)

    3. NM_201897.4 → NP_973626.2  NAD(P)-linked oxidoreductase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973626.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3H474, O80944, Q3E6N6, Q3EBK9, Q93YR4
      UniProtKB/TrEMBL
      A0A178VZ90, A0A5S9X4W0, A0A654FAD5
      Conserved Domains (1) summary
      cd19125
      Location:6 → 288
      AKR_AKR4C1-15; AKR4C family of aldo-keto reductase (AKR)

    4. NM_001084550.1 → NP_001078019.1  NAD(P)-linked oxidoreductase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078019.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FAD5
      Conserved Domains (2) summary
      COG0656
      Location:7 → 273
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:11 → 277
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    5. NM_201898.2 → NP_973627.1  NAD(P)-linked oxidoreductase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973627.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FAD5
      Conserved Domains (2) summary
      COG0656
      Location:7 → 273
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:11 → 277
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    6. NM_001124993.1 → NP_001118465.1  NAD(P)-linked oxidoreductase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118465.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FAD5
      Conserved Domains (2) summary
      COG0656
      Location:7 → 273
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:11 → 277
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    7. NM_001336674.1 → NP_001324985.1  NAD(P)-linked oxidoreductase superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B1V1, A0A654FAD5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O80944.2

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