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    gria1a glutamate receptor, ionotropic, AMPA 1a [ Danio rerio (zebrafish) ]

    Gene ID: 798689, updated on 11-Apr-2024

    Summary

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    Official Symbol
    gria1aprovided by ZNC
    Official Full Name
    glutamate receptor, ionotropic, AMPA 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020125-1
    See related
    Ensembl:ENSDARG00000021352 AllianceGenome:ZFIN:ZDB-GENE-020125-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    glur1a; gria1.1; ZfGluR1a; zfGRIA1[a]
    Summary
    Predicted to enable AMPA glutamate receptor activity and neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration. Predicted to act upstream of or within ion transport. Predicted to be located in postsynaptic membrane. Predicted to be integral component of membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in dendritic spine and plasma membrane. Is expressed in nervous system. Orthologous to human GRIA1 (glutamate ionotropic receptor AMPA type subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 14
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (34130584..34276608, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (33790295..33936303, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene LON peptidase N-terminal domain and ring finger 4 Neighboring gene mediator complex subunit 7 Neighboring gene protein Wnt-8a ORF2 Neighboring gene thymosin beta 2 Neighboring gene wingless-type MMTV integration site family, member 8a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identifications, classification, and evolution of the vertebrate alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor subunit genes. Chen YC, et al. J Mol Evol, 2001 Dec. PMID 11677629
    2. 6-Gingerol, a Major Constituent of Zingiber officinale Rhizoma, Exerts Anticonvulsant Activity in the Pentylenetetrazole-Induced Seizure Model in Larval Zebrafish. Gawel K, et al. Int J Mol Sci, 2021 Jul 20. PMID 34299361, Free PMC Article
    3. A novel zebrafish model of hyperthermia-induced seizures reveals a role for TRPV4 channels and NMDA-type glutamate receptors. Hunt RF, et al. Exp Neurol, 2012 Sep. PMID 22735490, Free PMC Article
    4. Glutamate Signaling via the AMPAR Subunit GluR4 Regulates Oligodendrocyte Progenitor Cell Migration in the Developing Spinal Cord. Piller M, et al. J Neurosci, 2021 Jun 23. PMID 33975920, Free PMC Article
    5. Expression of the eight AMPA receptor subunit genes in the developing central nervous system and sensory organs of zebrafish. Hoppmann V, et al. Dev Dyn, 2008 Mar. PMID 18224707

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables AMPA glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of AMPA glutamate receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutamate receptor 1; glutamate receptor 1a
    Names
    AMPA receptor subunit GluR1A
    Gria1b
    glutamate receptor, ionotropic, AMPA1.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205598.1 → NP_991161.1  glutamate receptor 1a precursor

      See identical proteins and their annotated locations for NP_991161.1

      Status: PROVISIONAL

      Source sequence(s)
      AF525741
      UniProtKB/TrEMBL
      Q71E65
      Related
      ENSDARP00000010256.8, ENSDART00000021437.10
      Conserved Domains (4) summary
      cd13729
      Location:404 → 806
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:536 → 836
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:36 → 369
      ANF_receptor; Receptor family ligand binding region
      cl10011
      Location:26 → 387
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      34130584..34276608 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173262.4 → XP_005173319.1  glutamate receptor 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BKK3
      Conserved Domains (4) summary
      cd13729
      Location:404 → 806
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:536 → 836
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:36 → 369
      ANF_receptor; Receptor family ligand binding region
      cl10011
      Location:26 → 387
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394918.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      241595..294100 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395316.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      302742..448469 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_3

    Genomic

    1. NW_018395386.1 Reference GRCz11 ALT_DRER_TU_3

      Range
      41014..170981 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_4

    Genomic

    1. NW_018395389.1 Reference GRCz11 ALT_DRER_TU_4

      Range
      40946..184983 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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