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    cplx3b complexin 3b [ Danio rerio (zebrafish) ]

    Gene ID: 794623, updated on 27-Mar-2024

    Summary

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    Official Symbol
    cplx3bprovided by ZNC
    Official Full Name
    complexin 3bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-091204-403
    See related
    Ensembl:ENSDARG00000089486 AllianceGenome:ZFIN:ZDB-GENE-091204-403
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch1073-122j16.1
    Summary
    Predicted to enable SNARE binding activity. Predicted to be involved in regulation of neurotransmitter secretion and synaptic vesicle exocytosis. Predicted to act upstream of or within exocytosis and neurotransmitter transport. Predicted to be located in synapse. Predicted to be part of SNARE complex. Predicted to be active in terminal bouton. Is expressed in female organism. Orthologous to human CPLX3 (complexin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 18
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (5677157..5703168, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (5807230..5822280, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101884251 Neighboring gene uncharacterized LOC110438080 Neighboring gene si:ch1073-459b3.2 Neighboring gene cell wall protein DAN4-like Neighboring gene CUB and zona pellucida-like domain-containing protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Stabilization of spontaneous neurotransmitter release at ribbon synapses by ribbon-specific subtypes of complexin. Vaithianathan T, et al. J Neurosci, 2013 May 8. PMID 23658160, Free PMC Article
    2. Enrichment and differential targeting of complexins 3 and 4 in ribbon-containing sensory neurons during zebrafish development. Zanazzi G, et al. Neural Dev, 2010 Sep 1. PMID 20809954, Free PMC Article
    3. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables syntaxin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neurotransmitter secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in terminal bouton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    complexin 3b; complexin-3b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001171590.1 → NP_001165061.1  complexin-3b

      See identical proteins and their annotated locations for NP_001165061.1

      Status: PROVISIONAL

      Source sequence(s)
      GU174498
      UniProtKB/TrEMBL
      A0A8M1NVS8, D2K290
      Related
      ENSDARP00000105392.2, ENSDART00000121503.3
      Conserved Domains (1) summary
      pfam05835
      Location:1 → 137
      Synaphin; Synaphin protein

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      5677157..5703168 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021467711.1 → XP_021323386.1  complexin 3b isoform X1

      UniProtKB/TrEMBL
      A0A8M1NVS8, D2K290
      Conserved Domains (1) summary
      pfam05835
      Location:1 → 137
      Synaphin; Synaphin protein
    Nucleotide Protein
    Heading Accession and Version

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