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    Arhgef10l Rho guanine nucleotide exchange factor 10-like [ Mus musculus (house mouse) ]

    Gene ID: 72754, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Arhgef10lprovided by MGI
    Official Full Name
    Rho guanine nucleotide exchange factor 10-likeprovided by MGI
    Primary source
    MGI:MGI:1920004
    See related
    Ensembl:ENSMUSG00000040964 AllianceGenome:MGI:1920004
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810441C07Rik
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in SREBP signaling pathway; actin cytoskeleton organization; and positive regulation of stress fiber assembly. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in brain. Human ortholog(s) of this gene implicated in ovarian endometrial cancer and ovarian serous carcinoma. Orthologous to human ARHGEF10L (Rho guanine nucleotide exchange factor 10 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon adult (RPKM 18.8), ovary adult (RPKM 14.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D3; 4 71.58 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (140241796..140393318, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (140514485..140666007, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 13021 Neighboring gene STARR-positive B cell enhancer mm9_chr4:140009533-140009834 Neighboring gene predicted gene, 54264 Neighboring gene STARR-seq mESC enhancer starr_11862 Neighboring gene STARR-positive B cell enhancer mm9_chr4:140142397-140142698 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:140157091-140157300 Neighboring gene predicted gene, 54265 Neighboring gene predicted gene, 42335 Neighboring gene STARR-seq mESC enhancer starr_11868 Neighboring gene STARR-positive B cell enhancer ABC_E6247 Neighboring gene STARR-seq mESC enhancer starr_11875 Neighboring gene predicted gene 13025 Neighboring gene regulator of chromosome condensation 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Investigating the effect of ARHGEF10L gene on tumor growth in gastric cancer in a nude mouse model using quantitative MRI parameters. Tang J, et al. J Cancer Res Ther, 2022 Dec. PMID 36647951
    2. GrinchGEF--a novel Rho-specific guanine nucleotide exchange factor. Winkler S, et al. Biochem Biophys Res Commun, 2005 Oct 7. PMID 16112081
    3. Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain. Yoshizawa M, et al. Gene Expr Patterns, 2003 Jun. PMID 12799088
    4. Class II histone deacetylases: versatile regulators. Verdin E, et al. Trends Genet, 2003 May. PMID 12711221
    5. Cleft lip and cleft palate in Esrp1 knockout mice is associated with alterations in epithelial-mesenchymal crosstalk. Lee S, et al. Development, 2020 Apr 30. PMID 32253237, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Investigating the effect of ARHGEF10L gene on tumor growth in gastric cancer in a nude mouse model using quantitative MRI parameters.
      Title: Investigating the effect of ARHGEF10L gene on tumor growth in gastric cancer in a nude mouse model using quantitative MRI parameters.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in SREBP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SREBP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of stress fiber assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 10-like protein
    Names
    GrinchGEF
    Rho guanine nucleotide exchange factor (GEF) 10-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001112722.1 → NP_001106193.1  rho guanine nucleotide exchange factor 10-like protein isoform b

      See identical proteins and their annotated locations for NP_001106193.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate, in-frame exon in the 5' coding region, compared to variant 4. It encodes isoform b, which is shorter than isoform d.
      Source sequence(s)
      AK028570, AK028648, AL954710, BC059220, BY026313
      Consensus CDS
      CCDS51343.1
      UniProtKB/TrEMBL
      A2AWP6
      Related
      ENSMUSP00000066249.6, ENSMUST00000069623.12
      Conserved Domains (3) summary
      cd00160
      Location:276 → 460
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam19056
      Location:748 → 1239
      WD40_2; WD40 repeated domain
      pfam19057
      Location:485 → 640
      PH_19; PH domain

    2. NM_001112723.1 → NP_001106194.1  rho guanine nucleotide exchange factor 10-like protein isoform c

      See identical proteins and their annotated locations for NP_001106194.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks two alternate in-frame exons in the 5' coding region, compared to variant 4. It encodes isoform c, which is shorter than isoform d.
      Source sequence(s)
      AK028648, AK129408, BC059220
      Consensus CDS
      CCDS51342.1
      UniProtKB/TrEMBL
      A2AWP6
      Related
      ENSMUSP00000095431.3, ENSMUST00000097820.9
      Conserved Domains (1) summary
      pfam00621
      Location:283 → 460
      RhoGEF; RhoGEF domain

    3. NM_001290803.1 → NP_001277732.1  rho guanine nucleotide exchange factor 10-like protein isoform d

      See identical proteins and their annotated locations for NP_001277732.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (d).
      Source sequence(s)
      BB612864, BB842000, BC059220, BQ558784, BX516814, CA751244, CF531696, CF532111, CX564261
      Consensus CDS
      CCDS71507.1
      UniProtKB/Swiss-Prot
      A2AWP5, A2AWP8, A2AWP9, A2AWQ0, A2AWQ1, Q6PCQ2, Q6ZPL3, Q8C1A1, Q8VDH5
      UniProtKB/TrEMBL
      A2AWP6
      Conserved Domains (3) summary
      cd00160
      Location:315 → 499
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam19056
      Location:787 → 1278
      WD40_2; WD40 repeated domain
      pfam19057
      Location:524 → 679
      PH_19; PH domain

    4. NM_172415.3 → NP_766003.3  rho guanine nucleotide exchange factor 10-like protein isoform a

      See identical proteins and their annotated locations for NP_766003.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 4. It encodes isoform a, which is shorter than isoform d.
      Source sequence(s)
      AK129408, BC059220, CF532111
      Consensus CDS
      CCDS51344.1
      UniProtKB/TrEMBL
      A2AWP6
      Related
      ENSMUSP00000040531.4, ENSMUST00000039204.10
      Conserved Domains (1) summary
      pfam00621
      Location:322 → 499
      RhoGEF; RhoGEF domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      140241796..140393318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253821.1 → XP_030109681.1  rho guanine nucleotide exchange factor 10-like protein isoform X3

      UniProtKB/TrEMBL
      A2AWP6
      Conserved Domains (1) summary
      pfam00621
      Location:322 → 499
      RhoGEF; RhoGEF domain

    2. XM_030253820.2 → XP_030109680.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

      UniProtKB/Swiss-Prot
      A2AWP5, A2AWP8, A2AWP9, A2AWQ0, A2AWQ1, Q6PCQ2, Q6ZPL3, Q8C1A1, Q8VDH5
      UniProtKB/TrEMBL
      A2AWP6
      Conserved Domains (3) summary
      cd00160
      Location:315 → 499
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam19056
      Location:787 → 1278
      WD40_2; WD40 repeated domain
      pfam19057
      Location:524 → 679
      PH_19; PH domain

    3. XM_030253822.1 → XP_030109682.1  rho guanine nucleotide exchange factor 10-like protein isoform X5

      UniProtKB/TrEMBL
      A2AWP6
      Conserved Domains (1) summary
      pfam00621
      Location:283 → 460
      RhoGEF; RhoGEF domain

    4. XM_036164470.1 → XP_036020363.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

      UniProtKB/Swiss-Prot
      A2AWP5, A2AWP8, A2AWP9, A2AWQ0, A2AWQ1, Q6PCQ2, Q6ZPL3, Q8C1A1, Q8VDH5
      UniProtKB/TrEMBL
      A2AWP6
      Conserved Domains (3) summary
      cd00160
      Location:315 → 499
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam19056
      Location:787 → 1278
      WD40_2; WD40 repeated domain
      pfam19057
      Location:524 → 679
      PH_19; PH domain

    5. XM_036164471.1 → XP_036020364.1  rho guanine nucleotide exchange factor 10-like protein isoform X4

      UniProtKB/TrEMBL
      A2AWP6
      Conserved Domains (3) summary
      cd00160
      Location:276 → 460
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam19056
      Location:748 → 1239
      WD40_2; WD40 repeated domain
      pfam19057
      Location:485 → 640
      PH_19; PH domain

    6. XM_006539202.1 → XP_006539265.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

      See identical proteins and their annotated locations for XP_006539265.1

      UniProtKB/Swiss-Prot
      A2AWP5, A2AWP8, A2AWP9, A2AWQ0, A2AWQ1, Q6PCQ2, Q6ZPL3, Q8C1A1, Q8VDH5
      UniProtKB/TrEMBL
      A2AWP6
      Related
      ENSMUSP00000101425.2, ENSMUST00000105799.8
      Conserved Domains (3) summary
      cd00160
      Location:315 → 499
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam19056
      Location:787 → 1278
      WD40_2; WD40 repeated domain
      pfam19057
      Location:524 → 679
      PH_19; PH domain

    7. XM_006539201.5 → XP_006539264.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

      See identical proteins and their annotated locations for XP_006539264.1

      UniProtKB/Swiss-Prot
      A2AWP5, A2AWP8, A2AWP9, A2AWQ0, A2AWQ1, Q6PCQ2, Q6ZPL3, Q8C1A1, Q8VDH5
      UniProtKB/TrEMBL
      A2AWP6
      Conserved Domains (3) summary
      cd00160
      Location:315 → 499
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam19056
      Location:787 → 1278
      WD40_2; WD40 repeated domain
      pfam19057
      Location:524 → 679
      PH_19; PH domain

    8. XM_017320396.3 → XP_017175885.1  rho guanine nucleotide exchange factor 10-like protein isoform X2

      UniProtKB/Swiss-Prot
      A2AWP5, A2AWP8, A2AWP9, A2AWQ0, A2AWQ1, Q6PCQ2, Q6ZPL3, Q8C1A1, Q8VDH5
      UniProtKB/TrEMBL
      A2AWP6
      Conserved Domains (3) summary
      cd00160
      Location:315 → 499
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam19056
      Location:787 → 1278
      WD40_2; WD40 repeated domain
      pfam19057
      Location:524 → 679
      PH_19; PH domain

    9. XM_011250337.4 → XP_011248639.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

      See identical proteins and their annotated locations for XP_011248639.1

      UniProtKB/Swiss-Prot
      A2AWP5, A2AWP8, A2AWP9, A2AWQ0, A2AWQ1, Q6PCQ2, Q6ZPL3, Q8C1A1, Q8VDH5
      UniProtKB/TrEMBL
      A2AWP6
      Conserved Domains (3) summary
      cd00160
      Location:315 → 499
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam19056
      Location:787 → 1278
      WD40_2; WD40 repeated domain
      pfam19057
      Location:524 → 679
      PH_19; PH domain

    10. XM_017320397.3 → XP_017175886.1  rho guanine nucleotide exchange factor 10-like protein isoform X7

      UniProtKB/TrEMBL
      A2AWP6
      Related
      ENSMUSP00000101423.3, ENSMUST00000105797.9
      Conserved Domains (1) summary
      pfam00621
      Location:105 → 282
      RhoGEF; RhoGEF domain

    11. XM_006539204.5 → XP_006539267.1  rho guanine nucleotide exchange factor 10-like protein isoform X6

      UniProtKB/TrEMBL
      A2AWP6
      Related
      ENSMUSP00000101424.2, ENSMUST00000105798.8
      Conserved Domains (1) summary
      cd00160
      Location:98 → 282
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    RNA

    1. XR_003955021.2 RNA Sequence

    2. XR_004941968.1 RNA Sequence

    3. XR_003955020.2 RNA Sequence

    4. XR_004941967.1 RNA Sequence

    5. XR_003955018.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AWP8.1 GenPept UniProtKB/Swiss-Prot:A2AWP8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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