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    Zfp444 zinc finger protein 444 [ Mus musculus (house mouse) ]

    Gene ID: 72667, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfp444provided by MGI
    Official Full Name
    zinc finger protein 444provided by MGI
    Primary source
    MGI:MGI:1923365
    See related
    Ensembl:ENSMUSG00000044876 AllianceGenome:MGI:1923365
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mFLJ00134; 2810031J10Rik; 6230401O10Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Orthologous to human ZNF444 (zinc finger protein 444). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 12.1), whole brain E14.5 (RPKM 10.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 A1; 7 3.58 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (6175429..6196103)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (6172468..6193104)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 18758 Neighboring gene zinc finger protein 787 Neighboring gene STARR-positive B cell enhancer ABC_E9284 Neighboring gene predicted gene, 36371 Neighboring gene STARR-positive B cell enhancer ABC_E4893 Neighboring gene STARR-seq mESC enhancer starr_17966 Neighboring gene galanin-like peptide Neighboring gene zinc finger and SCAN domain containing 5B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Allele-specific binding of ZFP57 in the epigenetic regulation of imprinted and non-imprinted monoallelic expression. Strogantsev R, et al. Genome Biol, 2015 May 30. PMID 26025256, Free PMC Article
    2. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    3. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Clone Names

    • FLJ00134

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 444

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146024.1 → NP_001139496.1  zinc finger protein 444

      See identical proteins and their annotated locations for NP_001139496.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC148989, AK018079, BC139361
      Consensus CDS
      CCDS20770.1
      UniProtKB/TrEMBL
      Q3TDV8, Q8BJ97
      Related
      ENSMUSP00000104206.2, ENSMUST00000108566.8
      Conserved Domains (4) summary
      COG5048
      Location:186 → 284
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:216 → 236
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:282 → 304
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:26 → 103
      SCAN; SCAN domain

    2. NM_028316.3 → NP_082592.2  zinc finger protein 444

      See identical proteins and their annotated locations for NP_082592.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC148989, AK018079, BC139361
      Consensus CDS
      CCDS20770.1
      UniProtKB/TrEMBL
      Q3TDV8, Q8BJ97
      Related
      ENSMUSP00000050797.6, ENSMUST00000054680.12
      Conserved Domains (4) summary
      COG5048
      Location:186 → 284
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:216 → 236
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:282 → 304
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:26 → 103
      SCAN; SCAN domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      6175429..6196103
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540381.5 → XP_006540444.1  zinc finger protein 444 isoform X1

      See identical proteins and their annotated locations for XP_006540444.1

      UniProtKB/TrEMBL
      Q3TDV8, Q8BJ97
      Conserved Domains (4) summary
      COG5048
      Location:186 → 284
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:216 → 236
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:282 → 304
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:26 → 103
      SCAN; SCAN domain

    2. XM_006540382.4 → XP_006540445.1  zinc finger protein 444 isoform X1

      See identical proteins and their annotated locations for XP_006540445.1

      UniProtKB/TrEMBL
      Q3TDV8, Q8BJ97
      Conserved Domains (4) summary
      COG5048
      Location:186 → 284
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:216 → 236
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:282 → 304
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:26 → 103
      SCAN; SCAN domain

    3. XM_006540380.5 → XP_006540443.1  zinc finger protein 444 isoform X1

      See identical proteins and their annotated locations for XP_006540443.1

      UniProtKB/TrEMBL
      Q3TDV8, Q8BJ97
      Conserved Domains (4) summary
      COG5048
      Location:186 → 284
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:216 → 236
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:282 → 304
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:26 → 103
      SCAN; SCAN domain

    4. XM_006540383.5 → XP_006540446.1  zinc finger protein 444 isoform X1

      See identical proteins and their annotated locations for XP_006540446.1

      UniProtKB/TrEMBL
      Q3TDV8, Q8BJ97
      Conserved Domains (4) summary
      COG5048
      Location:186 → 284
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:216 → 236
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:282 → 304
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:26 → 103
      SCAN; SCAN domain
    Nucleotide Protein Strain
    Heading Accession and Version

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