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    baiap2a BAR/IMD domain containing adaptor protein 2a [ Danio rerio (zebrafish) ]

    Gene ID: 678518, updated on 27-Mar-2024

    Summary

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    Official Symbol
    baiap2aprovided by ZNC
    Official Full Name
    BAR/IMD domain containing adaptor protein 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060421-2756
    See related
    Ensembl:ENSDARG00000062799 AllianceGenome:ZFIN:ZDB-GENE-060421-2756
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fk29g02; zgc:136827
    Summary
    Predicted to enable cytoskeletal anchor activity. Predicted to be involved in actin filament organization and positive regulation of cytoskeleton organization. Predicted to act upstream of or within plasma membrane organization and regulation of actin cytoskeleton organization. Predicted to be located in several cellular components, including cytoskeleton; filopodium; and ruffle. Predicted to be active in cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; attention deficit hyperactivity disorder; and autism spectrum disorder. Orthologous to human BAIAP2 (BAR/IMD domain containing adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (51684919..51893498)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (51430258..51638833)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene tweety homolog 2, like Neighboring gene uncharacterized LOC103910334 Neighboring gene charged multivesicular body protein 6a Neighboring gene apoptosis-associated tyrosine kinase a Neighboring gene alpha-(1,3)-fucosyltransferase 9-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Apelin signaling dependent endocardial protrusions promote cardiac trabeculation in zebrafish. Qi J, et al. Elife, 2022 Feb 28. PMID 35225788, Free PMC Article
    2. Regulation of the apical extension morphogenesis tunes the mechanosensory response of microvilliated neurons. Desban L, et al. PLoS Biol, 2019 Apr. PMID 31002663, Free PMC Article
    3. Dynamic filopodia are required for chemokine-dependent intracellular polarization during guided cell migration in vivo. Meyen D, et al. Elife, 2015 Apr 15. PMID 25875301, Free PMC Article
    4. Glucocorticoid activity detected by in vivo zebrafish assay and in vitro glucocorticoid receptor bioassay at environmental relevant concentrations. Chen Q, et al. Chemosphere, 2016 Feb. PMID 26461441
    5. An integrated approach with the zebrafish model for biomonitoring of municipal wastewater effluent and receiving waters. Li C, et al. Water Res, 2018 Mar 15. PMID 29258003

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC136827

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cytoskeletal anchor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin crosslink formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within plasma membrane organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in filopodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    brain-specific angiogenesis inhibitor 1-associated protein 2; brain-specific angiogenesis inhibitor 1-associated protein 2a
    Names
    BAI1-associated protein 2a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040245.1 → NP_001035335.1  brain-specific angiogenesis inhibitor 1-associated protein 2a

      See identical proteins and their annotated locations for NP_001035335.1

      Status: PROVISIONAL

      Source sequence(s)
      BC115281
      UniProtKB/TrEMBL
      Q1RLU7
      Related
      ENSDARP00000085613.6, ENSDART00000091180.7
      Conserved Domains (2) summary
      cd07646
      Location:3 → 234
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:386 → 444
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      51684919..51893498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009299775.3 → XP_009298050.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8M3AQY0
      Conserved Domains (2) summary
      cd07646
      Location:11 → 242
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:394 → 452
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53

    2. XM_005163755.4 → XP_005163812.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BAV5
      Conserved Domains (2) summary
      cd07646
      Location:11 → 242
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:394 → 452
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53

    3. XM_009299776.2 → XP_009298051.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X4

      See identical proteins and their annotated locations for XP_009298051.1

      UniProtKB/TrEMBL
      A0A8M3B8K0
      Conserved Domains (2) summary
      cd07646
      Location:11 → 242
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:394 → 452
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53

    4. XM_021471329.1 → XP_021327004.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PQ60
      Conserved Domains (2) summary
      cd07646
      Location:11 → 242
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:394 → 452
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53

    5. XM_021471351.1 → XP_021327026.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8M3B8K0
      Conserved Domains (2) summary
      cd07646
      Location:11 → 242
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:394 → 452
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    Nucleotide Protein Strain
    Heading Accession and Version

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