cfi complement factor I [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: cfiprovided by Xenbase
Official Full Name: complement factor Iprovided by Xenbase
Primary source: Xenbase:XB-GENE-5953276
See related: Ensembl:ENSXETG00000024110
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: kaf; ahus3; cfi-a; cfi-b; c3bina; c3b-ina; c3bc4bi
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	1	NC_030677.2 (68663007..68683452)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	1	NC_030677.1 (59179673..59211311)

Chromosome 1 - NC_030677.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: complement factor I

Names: complement factor 1

NP_001027508.1

EC 3.4.21.45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001032337.1 → NP_001027508.1 complement factor I precursor

See identical proteins and their annotated locations for NP_001027508.1

Status: PROVISIONAL

Source sequence(s)

BC098090

UniProtKB/TrEMBL

F6R1C4, F6R1S1, Q4V785

Related

ENSXETP00000052014.4, ENSXETT00000052014.4

Conserved Domains (4) summary

smart00057
Location:41 → 110

FIMAC; factor I membrane attack complex

smart00202
Location:114 → 202

SR; Scavenger receptor Cys-rich

cd00112
Location:222 → 256

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00190
Location:359 → 589

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...