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    JUN Jun proto-oncogene, AP-1 transcription factor subunit [ Canis lupus familiaris (dog) ]

    Gene ID: 609429, updated on 5-Mar-2024

    Summary

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    Official Symbol
    JUNprovided by VGNC
    Official Full Name
    Jun proto-oncogene, AP-1 transcription factor subunitprovided by VGNC
    Primary source
    VGNC:VGNC:42197
    See related
    Ensembl:ENSCAFG00845006541
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    AP-1; c-jun
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (51147773..51149113)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (51033459..51034786)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (51326980..51328311)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (51098106..51099438)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (51043349..51044688)

    Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102155586 Neighboring gene uncharacterized LOC119872023 Neighboring gene uncharacterized LOC102155678 Neighboring gene Myb like, SWIRM and MPN domains 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pentosan polysulfate inhibits IL-1β-induced iNOS, c-Jun and HIF-1α upregulation in canine articular chondrocytes. Bwalya EC, et al. PLoS One, 2017. PMID 28472120, Free PMC Article
    2. Inflammation-responsive transcription factors SAF-1 and c-Jun/c-Fos promote canine MMP-1 gene expression. Ray A, et al. Biochim Biophys Acta, 2005 Dec 30. PMID 16380175
    3. Hyperosmolarity-induced up-regulation of claudin-4 mediated by NADPH oxidase-dependent H2O2 production and Sp1/c-Jun cooperation. Ikari A, et al. Biochim Biophys Acta, 2013 Dec. PMID 23816505

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. demonstrate for the first time that PPS is a novel inhibitor of IL-1beta-induced iNOS, c-Jun, and HIF-1alpha mRNA upregulation and iNOS protein induction which may be beneficial for prevention and treatment OA
      Title: Pentosan polysulfate inhibits IL-1β-induced iNOS, c-Jun and HIF-1α upregulation in canine articular chondrocytes.
    2. hyperosmolarity increases nuclear Sp1/c-Jun complex and the association of the complex with the Sp1 binding site, resulting in the segment-specific expression of claudin-4 in the kidney.
      Title: Hyperosmolarity-induced up-regulation of claudin-4 mediated by NADPH oxidase-dependent H2O2 production and Sp1/c-Jun cooperation.
    3. results show that induction and activation of AP-1 and SAF-1 transcription factors are involved in the regulation of MMP-1 expression in the chondrocytes
      Title: Inflammation-responsive transcription factors SAF-1 and c-Jun/c-Fos promote canine MMP-1 gene expression.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor AP-1
    Names
    jun oncogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051809.1 Reference ROS_Cfam_1.0

      Range
      51147773..51149113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038666089.1 → XP_038522017.1  transcription factor AP-1

      UniProtKB/TrEMBL
      A0A8C0R052, A0A8C0Z0Z1, A0A8I3RTD9, A0A8P0TN96
      Related
      ENSCAFP00845009067.1, ENSCAFT00845011604.1
      Conserved Domains (2) summary
      cd14696
      Location:264 → 324
      bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain
      pfam03957
      Location:5 → 251
      Jun; Jun-like transcription factor

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049265.1 Alternate UMICH_Zoey_3.1

      Range
      51098106..51099438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038476209.1 → XP_038332137.1  transcription factor AP-1

      Conserved Domains (2) summary
      cd14696
      Location:264 → 324
      bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain
      pfam03957
      Location:5 → 251
      Jun; Jun-like transcription factor

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

      Range
      51043349..51044688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038601523.1 → XP_038457451.1  transcription factor AP-1

      Conserved Domains (2) summary
      cd14696
      Location:264 → 324
      bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain
      pfam03957
      Location:5 → 251
      Jun; Jun-like transcription factor

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

      Range
      51326980..51328311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038537394.1 → XP_038393322.1  transcription factor AP-1

      UniProtKB/TrEMBL
      A0A8I3RTD9, A0A8P0TN96

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      51033459..51034786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005620245.4 → XP_005620302.1  transcription factor AP-1

      UniProtKB/TrEMBL
      A0A8C0R052, A0A8C0Z0Z1, A0A8I3RTD9, A0A8P0TN96
      Conserved Domains (2) summary
      cd14696
      Location:264 → 324
      bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain
      pfam03957
      Location:5 → 251
      Jun; Jun-like transcription factor
    Nucleotide Protein
    Heading Accession and Version

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