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    Cnksr2 connector enhancer of kinase suppressor of Ras 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59322, updated on 31-Mar-2024

    Summary

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    Official Symbol
    Cnksr2provided by RGD
    Official Full Name
    connector enhancer of kinase suppressor of Ras 2provided by RGD
    Primary source
    RGD:708454
    See related
    Ensembl:ENSRNOG00000007014 AllianceGenome:RGD:708454
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables identical protein binding activity. Involved in postsynapse organization. Located in several cellular components, including neuronal cell body; postsynaptic density; and postsynaptic membrane. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in syndromic X-linked mental retardation Hough type. Orthologous to human CNKSR2 (connector enhancer of kinase suppressor of Ras 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 247.4), Muscle (RPKM 29.9) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    Xq21
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (40722843..40971730)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (36908135..37148337)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (39711001..39953860)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene NME/NM23 nucleoside diphosphate kinase 1, pseudogene 1 Neighboring gene kelch-like family member 34 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene small muscle protein, X-linked

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Disease-associated synaptic scaffold protein CNK2 modulates PSD size and influences localisation of the regulatory kinase TNIK. Zieger HL, et al. Sci Rep, 2020 Mar 31. PMID 32235845, Free PMC Article
    2. Synaptic localization of membrane-associated guanylate kinase-interacting protein mediated by the pleckstrin homology domain. Iida J, et al. Eur J Neurosci, 2002 May. PMID 12028359
    3. The CNK2 scaffold interacts with vilse and modulates Rac cycling during spine morphogenesis in hippocampal neurons. Lim J, et al. Curr Biol, 2014 Mar 31. PMID 24656827, Free PMC Article
    4. Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf. Lanigan TM, et al. FASEB J, 2003 Nov. PMID 14597674
    5. Densin-180, a synaptic protein, links to PSD-95 through its direct interaction with MAGUIN-1. Ohtakara K, et al. Genes Cells, 2002 Nov. PMID 12390249

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Disease-associated synaptic scaffold protein CNK2 modulates PSD size and influences localisation of the regulatory kinase TNIK.
      Title: Disease-associated synaptic scaffold protein CNK2 modulates PSD size and influences localisation of the regulatory kinase TNIK.
    2. MAGUIN-1 and -2 are recruited to synapses by the pleckstrin homology domain and that MAGUIN-1 subsequently interacts with PSD-95 at synapses.
      Title: Synaptic localization of membrane-associated guanylate kinase-interacting protein mediated by the pleckstrin homology domain.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in postsynapse organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in postsynapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synapse organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extrinsic component of postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extrinsic component of postsynaptic density membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    connector enhancer of kinase suppressor of ras 2
    Names
    CNK homolog protein 2
    CNK2
    connector enhancer of KSR 2
    maguin
    maguin-1
    maguin-2
    membrane-associated guanylate kinase-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113366.1 → NP_001106837.1  connector enhancer of kinase suppressor of ras 2 isoform 1

      See identical proteins and their annotated locations for NP_001106837.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AF102853, AF102854, JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q9R093, Q9Z1T4
      UniProtKB/TrEMBL
      A6IPN9
      Related
      ENSRNOP00000009802.3, ENSRNOT00000009802.6
      Conserved Domains (8) summary
      cd09511
      Location:8 → 76
      SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
      smart00454
      Location:8 → 73
      SAM; Sterile alpha motif
      cd00992
      Location:222 → 294
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01260
      Location:559 → 672
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam00169
      Location:573 → 669
      PH; PH domain
      pfam06663
      Location:341 → 561
      DUF1170; Protein of unknown function (DUF1170)
      pfam10534
      Location:84 → 176
      CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
      pfam15499
      Location:139 → 218
      Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase

    2. NM_021686.3 → NP_067718.1  connector enhancer of kinase suppressor of ras 2 isoform 2

      See identical proteins and their annotated locations for NP_067718.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 3' sequence, as compared to variant 1. The resulting isoform (2) has a shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      AF102854, JAXUCZ010000021
      UniProtKB/TrEMBL
      A6IPP1
      Related
      ENSRNOP00000071915.1, ENSRNOT00000080512.2
      Conserved Domains (8) summary
      cd09511
      Location:8 → 76
      SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
      smart00454
      Location:8 → 73
      SAM; Sterile alpha motif
      cd00992
      Location:222 → 294
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01260
      Location:559 → 672
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam00169
      Location:573 → 669
      PH; PH domain
      pfam06663
      Location:341 → 561
      DUF1170; Protein of unknown function (DUF1170)
      pfam10534
      Location:84 → 176
      CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
      pfam15499
      Location:139 → 218
      Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      40722843..40971730
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017602144.3 → XP_017457633.1  connector enhancer of kinase suppressor of ras 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A0Z8, A6IPP0
      Related
      ENSRNOP00000084300.1
      Conserved Domains (8) summary
      cd09511
      Location:8 → 76
      SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
      smart00454
      Location:8 → 73
      SAM; Sterile alpha motif
      cd00992
      Location:222 → 270
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01260
      Location:510 → 623
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam00169
      Location:524 → 620
      PH; PH domain
      pfam06663
      Location:292 → 512
      DUF1170; Protein of unknown function (DUF1170)
      pfam10534
      Location:84 → 176
      CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
      pfam15499
      Location:139 → 218
      Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase

    2. XM_063280272.1 → XP_063136342.1  connector enhancer of kinase suppressor of ras 2 isoform X4

    3. XM_039100001.2 → XP_038955929.1  connector enhancer of kinase suppressor of ras 2 isoform X3

      Conserved Domains (5) summary
      cd09511
      Location:8 → 76
      SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
      cd00992
      Location:222 → 270
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01260
      Location:480 → 593
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam06663
      Location:290 → 408
      DUF1170; Protein of unknown function (DUF1170)
      pfam10534
      Location:84 → 176
      CRIC_ras_sig; Connector enhancer of kinase suppressor of ras

    4. XM_008773224.4 → XP_008771446.1  connector enhancer of kinase suppressor of ras 2 isoform X1

      Conserved Domains (8) summary
      cd09511
      Location:8 → 76
      SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
      smart00454
      Location:8 → 73
      SAM; Sterile alpha motif
      cd00992
      Location:222 → 294
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01260
      Location:529 → 642
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam00169
      Location:543 → 639
      PH; PH domain
      pfam06663
      Location:341 → 531
      DUF1170; Protein of unknown function (DUF1170)
      pfam10534
      Location:84 → 176
      CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
      pfam15499
      Location:139 → 218
      Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z1T4.1 GenPept UniProtKB/Swiss-Prot:Q9Z1T4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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