Adcy10 adenylate cyclase 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adcy10provided by RGD
Official Full Name: adenylate cyclase 10provided by RGD
Primary source: RGD:708450
See related: Ensembl:ENSRNOG00000053410 AllianceGenome:RGD:708450
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sac
Summary: Enables ATPase binding activity; adenylate cyclase activity; and manganese ion binding activity. Involved in cAMP biosynthetic process and positive regulation of apoptotic process. Located in several cellular components, including basal part of cell; growth cone; and neuronal cell body. Orthologous to human ADCY10 (adenylate cyclase 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 147.9), Liver (RPKM 19.0) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q23

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (80280595..80366939)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (77747752..77833952)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (83701952..83787010)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the sAC( type 10 soluble adenylyl cyclase)-EPAC axis may regulate basal and induced AMPK activity and support mitophagy, cellular energy and redox homeostasis. The study argues for sAC as a potential target in treating pathologies associated with AMPK downregulation
Title: Regulation of AMPK activity by type 10 adenylyl cyclase: contribution to the mitochondrial biology, cellular redox and energy homeostasis.
within the pulmonary circulation, AC10 is expressed in pulmonary microvascular endothelial cells (PMVECs) and pulmonary artery endothelial cells (PAECs), yet expression in PAECs is lower.
Title: Bicarbonate disruption of the pulmonary endothelial barrier via activation of endogenous soluble adenylyl cyclase, isoform 10.
activation of sAC in the pancreatic acinar cell has a protective effect and reduces the pathologic activation of proteases during pancreatitis
Title: Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells.
a key role of soluble adenylyl cyclase in simulated in vitro ischaemia induced mitochondrial Bax translocation and activation of the mitochondrial pathway of apoptosis in adult cardiomyocytes.
Title: Type 10 adenylyl cyclase mediates mitochondrial Bax translocation and apoptosis of adult rat cardiomyocytes under simulated ischaemia/reperfusion.
These results suggest the important role of sAC in modulating the mitochondria-dependent pathway of apoptosis in endothelial cells.
Title: Soluble adenylyl cyclase controls mitochondria-dependent apoptosis in coronary endothelial cells.
description of a novel pathway for pH regulation linking the bicarbonate activated soluble adenylyl cyclase to the vacuolar H+ATPase
Title: Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling.
adenylyl cyclase mediates nerve growth factor-induced activation of Rap1
Title: Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1.

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General gene information

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Markers

Adcy10 (e-PCR), detects polymorphism
- UniSTS:527118

Adcy10 (e-PCR), detects polymorphism
- UniSTS:527119

BF390833 (e-PCR)
- UniSTS:249585

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables bicarbonate binding	ISO Inferred from Sequence Orthology more info
enables bicarbonate binding	ISS Inferred from Sequence or Structural Similarity more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cAMP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cAMP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cAMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to inorganic substance	ISO Inferred from Sequence Orthology more info
involved_in cellular response to inorganic substance	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelial cilium movement involved in extracellular fluid movement	ISO Inferred from Sequence Orthology more info
involved_in epithelial cilium movement involved in extracellular fluid movement	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial ATP transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cardiac muscle cell contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitochondrial membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of reactive oxygen species biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection retraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ATP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardiac muscle hypertrophy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glycogen catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of intrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of mitochondrial depolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-threonine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein targeting to mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of reactive oxygen species biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of membrane repolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatid development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in astrocyte end-foot	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in basal part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in central region of growth cone	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in motile cilium	ISO Inferred from Sequence Orthology more info
located_in motile cilium	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: adenylate cyclase type 10

Names: adenylate cyclase 10 (soluble); germ cell soluble adenylyl cyclase; soluble adenylyl cyclase; testicular soluble adenylyl cyclase

NP_067716.1

EC 4.6.1.1

XP_008767899.1

EC 4.6.1.1

XP_008767900.1

EC 4.6.1.1

XP_038946977.1

EC 4.6.1.1

XP_038946978.1

EC 4.6.1.1

XP_038946979.1

EC 4.6.1.1

XP_038946980.1

EC 4.6.1.1

XP_063128634.1

EC 4.6.1.1

XP_063128635.1

EC 4.6.1.1

XP_063128636.1

EC 4.6.1.1

XP_063128637.1

EC 4.6.1.1

XP_063128638.1

EC 4.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021684.1 → NP_067716.1 adenylate cyclase type 10

See identical proteins and their annotated locations for NP_067716.1

Status: PROVISIONAL

Source sequence(s)

AF081941

UniProtKB/Swiss-Prot

Q9Z286

Conserved Domains (3) summary

cd07302
Location:40 → 214

CHD; cyclase homology domain

COG2114
Location:42 → 197

AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]

pfam13191
Location:485 → 670

AAA_16; AAA ATPase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

80280595..80366939

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272565.1 → XP_063128635.1 adenylate cyclase type 10 isoform X2
XM_063272564.1 → XP_063128634.1 adenylate cyclase type 10 isoform X1

UniProtKB/Swiss-Prot

Q9Z286
XM_008769677.4 → XP_008767899.1 adenylate cyclase type 10 isoform X1

See identical proteins and their annotated locations for XP_008767899.1

UniProtKB/Swiss-Prot

Q9Z286

Conserved Domains (3) summary

cd07302
Location:40 → 214

CHD; cyclase homology domain

COG2114
Location:42 → 197

AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]

pfam13191
Location:485 → 670

AAA_16; AAA ATPase domain
XM_008769678.4 → XP_008767900.1 adenylate cyclase type 10 isoform X1

See identical proteins and their annotated locations for XP_008767900.1

UniProtKB/Swiss-Prot

Q9Z286

Conserved Domains (3) summary

cd07302
Location:40 → 214

CHD; cyclase homology domain

COG2114
Location:42 → 197

AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]

pfam13191
Location:485 → 670

AAA_16; AAA ATPase domain
XM_063272566.1 → XP_063128636.1 adenylate cyclase type 10 isoform X4
XM_063272567.1 → XP_063128637.1 adenylate cyclase type 10 isoform X8
XM_039091049.2 → XP_038946977.1 adenylate cyclase type 10 isoform X3

Conserved Domains (1) summary

cd07302
Location:22 → 162

CHD; cyclase homology domain
XM_039091050.1 → XP_038946978.1 adenylate cyclase type 10 isoform X5
XM_039091051.1 → XP_038946979.1 adenylate cyclase type 10 isoform X6
XM_039091052.1 → XP_038946980.1 adenylate cyclase type 10 isoform X7
XM_063272568.1 → XP_063128638.1 adenylate cyclase type 10 isoform X9