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    scn4aa sodium channel, voltage-gated, type IV, alpha, a [ Danio rerio (zebrafish) ]

    Gene ID: 572442, updated on 11-Apr-2024

    Summary

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    Official Symbol
    scn4aaprovided by ZNC
    Official Full Name
    sodium channel, voltage-gated, type IV, alpha, aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-051201-2
    See related
    Ensembl:ENSDARG00000098738 AllianceGenome:ZFIN:ZDB-GENE-051201-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Nav1.4a; Na<sub>v</sub>1.4a
    Summary
    Predicted to enable voltage-gated sodium channel activity. Predicted to be involved in membrane depolarization during action potential; neuronal action potential; and sodium ion transmembrane transport. Predicted to act upstream of or within regulation of ion transmembrane transport; sodium ion transport; and transmembrane transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in axon. Is expressed in heart; musculature system; nervous system; pectoral fin; and testis. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 16; hyperkalemic periodic paralysis; and paramyotonia congenita of Von Eulenburg. Orthologous to human SCN4A (sodium voltage-gated channel alpha subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See scn4aa in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (4856435..4893651)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (4834291..4858822)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene zgc:163073 Neighboring gene growth hormone releasing hormone receptor 2 Neighboring gene CD79b molecule, immunoglobulin-associated beta Neighboring gene interferon phi 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Genetic basis of tetrodotoxin resistance in pufferfishes. Venkatesh B, et al. Curr Biol, 2005 Nov 22. PMID 16303569
    2. ZBTB42 mutation defines a novel lethal congenital contracture syndrome (LCCS6). Patel N, et al. Hum Mol Genet, 2014 Dec 15. PMID 25055871, Free PMC Article
    3. Characterization of Na+ and Ca2+ channels in zebrafish dorsal root ganglion neurons. Won YJ, et al. PLoS One, 2012. PMID 22880050, Free PMC Article
    4. Embryonic and larval expression of zebrafish voltage-gated sodium channel alpha-subunit genes. Novak AE, et al. Dev Dyn, 2006 Jul. PMID 16615064
    5. Cardiac voltage-gated sodium channel expression and electrophysiological characterization of the sodium current in the zebrafish (Danio rerio) ventricle. Haverinen J, et al. Prog Biophys Mol Biol, 2018 Oct. PMID 29655910

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables monoatomic cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in membrane depolarization during action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuronal action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated sodium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated sodium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sodium channel protein type 4 subunit alpha A
    Names
    voltage-gated sodium channel Nav1.4a
    voltage-gated sodium channel subunit alpha Nav1.4a
    zscn3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039825.1 → NP_001034914.1  sodium channel protein type 4 subunit alpha A

      See identical proteins and their annotated locations for NP_001034914.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ221253
      UniProtKB/Swiss-Prot
      Q20JQ6, Q2XVR3
      Conserved Domains (4) summary
      cd13433
      Location:1262 → 1314
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1014 → 1270
      Ion_trans; Ion transport protein
      pfam06512
      Location:820 → 992
      Na_trans_assoc; Sodium ion transport-associated
      pfam16905
      Location:1584 → 1641
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      4856435..4893651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017358479.2 → XP_017213968.1  sodium channel protein type 4 subunit alpha A isoform X1

      UniProtKB/TrEMBL
      A0A0R4IJX4, A0A8M6Z1C6
      Related
      ENSDARP00000134593.1, ENSDART00000170961.2
      Conserved Domains (4) summary
      cd13433
      Location:1262 → 1314
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1014 → 1270
      Ion_trans; Ion transport protein
      pfam06512
      Location:820 → 992
      Na_trans_assoc; Sodium ion transport-associated
      pfam16905
      Location:1584 → 1641
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394829.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      51019..75228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2XVR3.2 GenPept UniProtKB/Swiss-Prot:Q2XVR3

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