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    zdhhc12b zinc finger DHHC-type palmitoyltransferase 12b [ Danio rerio (zebrafish) ]

    Gene ID: 569129, updated on 27-Mar-2024

    Summary

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    Official Symbol
    zdhhc12bprovided by ZNC
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 12bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070705-356
    See related
    Ensembl:ENSDARG00000052787 AllianceGenome:ZFIN:ZDB-GENE-070705-356
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-202g15.2
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation and protein targeting to membrane. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC12 (zinc finger DHHC-type palmitoyltransferase 12). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (31820251..31828374)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (31220134..31227034)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 25b Neighboring gene UDP-N-acetylglucosamine pyrophosphorylase 1, like 1 Neighboring gene protein kinase N3 Neighboring gene iron-sulfur cluster assembly enzyme b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. 2-Bromopalmitate impairs neural stem/progenitor cell proliferation, promotes cell apoptosis and induces malformation in zebrafish embryonic brain. Wang C, et al. Neurotoxicol Teratol, 2015 Jul-Aug. PMID 26056731
    2. Protein palmitoylation activate zygotic gene expression during the maternal-to-zygotic transition. Du Z, et al. Biochem Biophys Res Commun, 2016 Jun 24. PMID 27235108
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of NLRP3 inflammasome complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptidyl-L-cysteine S-palmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable palmitoyltransferase ZDHHC12
    Names
    zdhhc12
    zinc finger DHHC-type containing 12b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      31820251..31828374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476502.1 → XP_021332177.1  probable palmitoyltransferase ZDHHC12 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PL33
      Conserved Domains (1) summary
      pfam01529
      Location:97 → 168
      zf-DHHC; DHHC palmitoyltransferase

    2. XM_692494.8 → XP_697586.4  probable palmitoyltransferase ZDHHC12 isoform X1

      UniProtKB/Swiss-Prot
      E7F021
      Related
      ENSDARP00000099963.2, ENSDART00000110974.4
      Conserved Domains (1) summary
      pfam01529
      Location:97 → 171
      DHHC; DHHC palmitoyltransferase

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394585.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      134314..143372
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021471614.1 → XP_021327289.1  probable palmitoyltransferase ZDHHC12 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PQZ2
      Conserved Domains (1) summary
      pfam01529
      Location:97 → 171
      zf-DHHC; DHHC palmitoyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E7F021.1 GenPept UniProtKB/Swiss-Prot:E7F021

    Gene LinkOut

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