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    adcy7 adenylate cyclase 7 [ Danio rerio (zebrafish) ]

    Gene ID: 568726, updated on 11-Apr-2024

    Summary

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    Official Symbol
    adcy7provided by ZNC
    Official Full Name
    adenylate cyclase 7provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040713-1
    See related
    Ensembl:ENSDARG00000060070 AllianceGenome:ZFIN:ZDB-GENE-040713-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ADCY4a
    Summary
    Predicted to enable adenylate cyclase activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within cAMP biosynthetic process and intracellular signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Orthologous to human ADCY7 (adenylate cyclase 7). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 7
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (37767124..37858598, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (37496252..37587323, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene NKD inhibitor of WNT signaling pathway 1 Neighboring gene bromodomain containing 7 Neighboring gene terminal nucleotidyltransferase 4B Neighboring gene HEAT repeat containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Dydrogesterone affects the transcription of genes in GnRH and steroidogenesis pathways and increases the frequency of atretic follicles in zebrafish (Danio rerio). Shi WJ, et al. Chemosphere, 2019 Feb. PMID 30391894
    2. The progestin norethindrone alters growth, reproductive histology and gene expression in zebrafish (Danio rerio). Liang YQ, et al. Chemosphere, 2020 Mar. PMID 31896209
    3. Transcriptional and Biochemical Alterations in Zebrafish Eleuthero-Embryos (Danio rerio) After Exposure to Synthetic Progestogen Dydrogesterone. Shi WJ, et al. Bull Environ Contam Toxicol, 2017 Jul. PMID 28214940
    4. Organization of Iroquois genes in fish. Dildrop R, et al. Dev Genes Evol, 2004 Jun. PMID 15133664
    5. n-3 PUFA reduction caused by fabp2 deletion interferes with triacylglycerol metabolism and cholesterolhomeostasis in fish. Zhao Y, et al. Appl Microbiol Biotechnol, 2020 Mar. PMID 31950220

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorus-oxygen lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cAMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cAMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adenylate cyclase type 7
    NP_001159744.2
    XP_009301597.1
    XP_021333246.1
    XP_021333247.1
    XP_021333249.1
    XP_021333250.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166272.2 → NP_001159744.2  adenylate cyclase type 7

      See identical proteins and their annotated locations for NP_001159744.2

      Status: VALIDATED

      Source sequence(s)
      BX663605
      UniProtKB/TrEMBL
      A0A0R4IFB6, A0A286YBZ2, A0A8M1NU38
      Related
      ENSDARP00000132036.2, ENSDART00000164485.2
      Conserved Domains (4) summary
      smart00044
      Location:223 → 431
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:874 → 1071
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:487 → 593
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:129 → 248
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      37767124..37858598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021477575.1 → XP_021333250.1  adenylate cyclase type 7 isoform X5

      UniProtKB/TrEMBL
      A0A8M9QH45
      Related
      ENSDARP00000142704.1, ENSDART00000173552.2
      Conserved Domains (3) summary
      pfam00211
      Location:888 → 1085
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:487 → 592
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:129 → 248
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    2. XM_021477574.1 → XP_021333249.1  adenylate cyclase type 7 isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q7Y4
      Conserved Domains (3) summary
      pfam00211
      Location:889 → 1086
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:487 → 593
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:129 → 248
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    3. XM_021477572.1 → XP_021333247.1  adenylate cyclase type 7 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PP18
      Conserved Domains (3) summary
      pfam00211
      Location:908 → 1105
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:487 → 612
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:129 → 248
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    4. XM_009303322.3 → XP_009301597.1  adenylate cyclase type 7 isoform X3

      See identical proteins and their annotated locations for XP_009301597.1

      UniProtKB/TrEMBL
      A0A8M3AUC6
      Related
      ENSDARP00000107915.2, ENSDART00000129156.4
      Conserved Domains (4) summary
      smart00044
      Location:223 → 431
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:894 → 1091
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:487 → 613
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:129 → 248
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    5. XM_021477571.1 → XP_021333246.1  adenylate cyclase type 7 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QC34
      Conserved Domains (3) summary
      pfam00211
      Location:909 → 1106
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:487 → 613
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:129 → 248
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    Nucleotide Protein Strain
    Heading Accession and Version

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