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    slc9a3.1 solute carrier family 9 member A3, tandem duplicate 1 [ Danio rerio (zebrafish) ]

    Gene ID: 568258, updated on 11-Apr-2024

    Summary

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    Official Symbol
    slc9a3.1provided by ZNC
    Official Full Name
    solute carrier family 9 member A3, tandem duplicate 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060503-545
    See related
    Ensembl:ENSDARG00000058498 AllianceGenome:ZFIN:ZDB-GENE-060503-545
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    nhe3a; si:dkey-3n22.4
    Summary
    Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to act upstream of or within regulation of pH; sodium ion transport; and transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in apical plasma membrane and brush border membrane. Is expressed in kidney. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 8. Orthologous to human SLC9A3 (solute carrier family 9 member A3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 19
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (10692166..10730478, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (10773244..10811592, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene oleoyl-ACP hydrolase Neighboring gene argonaute RISC catalytic component 3b Neighboring gene solute carrier family 9 member A3, tandem duplicate 2 Neighboring gene si:dkey-3n22.9 Neighboring gene lipase, hormone-sensitive a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Gene expression of Na+/H+ exchanger in zebrafish H+ -ATPase-rich cells during acclimation to low-Na+ and acidic environments. Yan JJ, et al. Am J Physiol Cell Physiol, 2007 Dec. PMID 17913841
    2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium:proton antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of pH IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in brush border membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sodium/hydrogen exchanger 3.1; solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3, tandem duplicate 1
    Names
    sodium hydrogen exchanger 3a
    solute carrier family 9 (sodium/hydrogen exchanger), member 3, tandem duplicate 1
    solute carrier family 9 (sodium/hydrogen exchanger), member 3.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113473.1 → NP_001106944.1  sodium/hydrogen exchanger 3.1 precursor

      See identical proteins and their annotated locations for NP_001106944.1

      Status: PROVISIONAL

      Source sequence(s)
      EF591984
      UniProtKB/TrEMBL
      A9XPA1
      Related
      ENSDARP00000075793.4, ENSDART00000081350.6
      Conserved Domains (2) summary
      TIGR00840
      Location:50 → 563
      b_cpa1; sodium/hydrogen exchanger 3
      pfam00999
      Location:60 → 465
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      10692166..10730478 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159457.4 → XP_005159514.1  solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3, tandem duplicate 1 isoform X1

      See identical proteins and their annotated locations for XP_005159514.1

      UniProtKB/TrEMBL
      A0A8M2B665, B7ZVJ6
      Related
      ENSDARP00000107289.3, ENSDART00000126033.5
      Conserved Domains (2) summary
      TIGR00840
      Location:50 → 563
      b_cpa1; sodium/hydrogen exchanger 3
      pfam00999
      Location:60 → 465
      Na_H_Exchanger; Sodium/hydrogen exchanger family
    Nucleotide Protein
    Heading Accession and Version

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