U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    cnnm2b cyclin and CBS domain divalent metal cation transport mediator 2b [ Danio rerio (zebrafish) ]

    Gene ID: 565702, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cnnm2bprovided by ZNC
    Official Full Name
    cyclin and CBS domain divalent metal cation transport mediator 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090311-26
    See related
    Ensembl:ENSDARG00000078733 AllianceGenome:ZFIN:ZDB-GENE-090311-26
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-176l1.6
    Summary
    Acts upstream of or within brain development and magnesium ion homeostasis. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including digestive system; heart; opercular flap; pleuroperitoneal region; and scale. Used to study schizophrenia. Human ortholog(s) of this gene implicated in renal hypomagnesemia 6. Orthologous to human CNNM2 (cyclin and CBS domain divalent metal cation transport mediator 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (31724623..31799358)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (30992003..31066790)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene WW domain binding protein 1-like b Neighboring gene arsenite methyltransferase Neighboring gene 5'-nucleotidase, cytosolic IIb Neighboring gene internexin neuronal intermediate filament protein, alpha b

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Evidence for widespread subfunctionalization of splice forms in vertebrate genomes. Lambert MJ, et al. Genome Res, 2015 May. PMID 25792610, Free PMC Article
    2. CNNM2 mutations cause impaired brain development and seizures in patients with hypomagnesemia. Arjona FJ, et al. PLoS Genet, 2014 Apr. PMID 24699222, Free PMC Article
    3. SLC41A1 is essential for magnesium homeostasis in vivo. Arjona FJ, et al. Pflugers Arch, 2019 Jun. PMID 30417250, Free PMC Article
    4. Studies in Zebrafish Demonstrate That CNNM2 and NT5C2 Are Most Likely the Causal Genes at the Blood Pressure-Associated Locus on Human Chromosome 10q24.32. Vishnolia KK, et al. Front Cardiovasc Med, 2020. PMID 32984406, Free PMC Article
    5. Tissue-specific expression and in vivo regulation of zebrafish orthologues of mammalian genes related to symptomatic hypomagnesemia. Arjona FJ, et al. Pflugers Arch, 2013 Oct. PMID 23636770

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within magnesium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within magnesium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    metal transporter CNNM2
    Names
    cnnm2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      31724623..31799358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009292266.3 → XP_009290541.1  metal transporter CNNM2 isoform X2

      UniProtKB/TrEMBL
      A0A8M3AJ29
      Conserved Domains (2) summary
      cd04590
      Location:410 → 530
      CBS_pair_CorC_HlyC_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in ...
      pfam01595
      Location:212 → 386
      DUF21; Domain of unknown function DUF21

    2. XM_001922770.7 → XP_001922805.4  metal transporter CNNM2 isoform X1

      UniProtKB/TrEMBL
      A0A8M1QVA5, F1QIW8
      Related
      ENSDARP00000098293.4, ENSDART00000112333.6
      Conserved Domains (2) summary
      cd04590
      Location:410 → 530
      CBS_pair_CorC_HlyC_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in ...
      pfam01595
      Location:212 → 386
      DUF21; Domain of unknown function DUF21
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools