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    kcnc3b potassium voltage-gated channel, Shaw-related subfamily, member 3b [ Danio rerio (zebrafish) ]

    Gene ID: 564371, updated on 11-Apr-2024

    Summary

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    Official Symbol
    kcnc3bprovided by ZNC
    Official Full Name
    potassium voltage-gated channel, Shaw-related subfamily, member 3bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-100901-2
    See related
    Ensembl:ENSDARG00000098816 AllianceGenome:ZFIN:ZDB-GENE-100901-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable voltage-gated potassium channel activity. Predicted to act upstream of or within potassium ion transmembrane transport; protein homooligomerization; and regulation of ion transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of voltage-gated potassium channel complex. Is expressed in cerebellum. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 13. Orthologous to human KCNC3 (potassium voltage-gated channel subfamily C member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See kcnc3b in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (37061182..37184846)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (37086321..37125705)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103909775 Neighboring gene uncharacterized LOC110438363 Neighboring gene component of oligomeric golgi complex 7 Neighboring gene uncharacterized LOC101886719

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Modeling Neurodegenerative Spinocerebellar Ataxia Type 13 in Zebrafish Using a Purkinje Neuron Specific Tunable Coexpression System. Namikawa K, et al. J Neurosci, 2019 May 15. PMID 30862666, Free PMC Article
    2. Functional effects of spinocerebellar ataxia type 13 mutations are conserved in zebrafish Kv3.3 channels. Mock AF, et al. BMC Neurosci, 2010 Aug 16. PMID 20712895, Free PMC Article
    3. The developmental effects of pentachlorophenol on zebrafish embryos during segmentation: A systematic view. Xu T, et al. Sci Rep, 2016 May 16. PMID 27181905, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    potassium voltage-gated channel subfamily C member 3b; potassium voltage-gated channel, Shaw-related subfamily, member 3b
    Names
    potassium voltage-gated channel subfamily C member 1 pseudogene
    voltage-gated potassium channel Kv3.3b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195241.1 → NP_001182170.1  potassium voltage-gated channel subfamily C member 3b

      See identical proteins and their annotated locations for NP_001182170.1

      Status: PROVISIONAL

      Source sequence(s)
      HQ118214
      UniProtKB/TrEMBL
      A0A0G2L1J1, A0A8M9PXL1, E1AZA6
      Related
      ENSDARP00000138600.2, ENSDART00000159942.2
      Conserved Domains (3) summary
      pfam00520
      Location:205 → 463
      Ion_trans; Ion transport protein
      pfam02214
      Location:38 → 132
      BTB_2; BTB/POZ domain
      pfam11404
      Location:1 → 29
      Potassium_chann; Potassium voltage-gated channel

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      37061182..37184846
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021470206.1 → XP_021325881.1  potassium voltage-gated channel, Shaw-related subfamily, member 3b isoform X4

      UniProtKB/TrEMBL
      A0A8M9PU62
      Conserved Domains (3) summary
      pfam00520
      Location:205 → 463
      Ion_trans; Ion transport protein
      pfam02214
      Location:38 → 132
      BTB_2; BTB/POZ domain
      pfam11404
      Location:1 → 29
      Potassium_chann; Potassium voltage-gated channel

    2. XM_021470207.1 → XP_021325882.1  potassium voltage-gated channel, Shaw-related subfamily, member 3b isoform X5

      UniProtKB/TrEMBL
      A0A8M9P5Y6
      Conserved Domains (3) summary
      pfam00520
      Location:205 → 463
      Ion_trans; Ion transport protein
      pfam02214
      Location:38 → 132
      BTB_2; BTB/POZ domain
      pfam11404
      Location:1 → 29
      Potassium_chann; Potassium voltage-gated channel

    3. XM_021470208.1 → XP_021325883.1  potassium voltage-gated channel, Shaw-related subfamily, member 3b isoform X6

      UniProtKB/TrEMBL
      A0A8M9PG40
      Conserved Domains (3) summary
      pfam00520
      Location:205 → 463
      Ion_trans; Ion transport protein
      pfam02214
      Location:38 → 132
      BTB_2; BTB/POZ domain
      pfam11404
      Location:1 → 29
      Potassium_chann; Potassium voltage-gated channel

    4. XM_021470204.1 → XP_021325879.1  potassium voltage-gated channel, Shaw-related subfamily, member 3b isoform X2

      UniProtKB/TrEMBL
      A0A8M9PLW2
      Conserved Domains (3) summary
      pfam00520
      Location:205 → 463
      Ion_trans; Ion transport protein
      pfam02214
      Location:38 → 132
      BTB_2; BTB/POZ domain
      pfam11404
      Location:1 → 29
      Potassium_chann; Potassium voltage-gated channel

    5. XM_021470205.1 → XP_021325880.1  potassium voltage-gated channel, Shaw-related subfamily, member 3b isoform X3

      UniProtKB/TrEMBL
      A0A0G2L1J1, A0A8M9PXL1, E1AZA6
      Conserved Domains (3) summary
      pfam00520
      Location:205 → 463
      Ion_trans; Ion transport protein
      pfam02214
      Location:38 → 132
      BTB_2; BTB/POZ domain
      pfam11404
      Location:1 → 29
      Potassium_chann; Potassium voltage-gated channel

    6. XM_021470203.1 → XP_021325878.1  potassium voltage-gated channel, Shaw-related subfamily, member 3b isoform X1

      UniProtKB/TrEMBL
      A0A8M9PG37
      Conserved Domains (3) summary
      pfam00520
      Location:205 → 463
      Ion_trans; Ion transport protein
      pfam02214
      Location:38 → 132
      BTB_2; BTB/POZ domain
      pfam11404
      Location:1 → 29
      Potassium_chann; Potassium voltage-gated channel
    Nucleotide Protein Strain
    Heading Accession and Version

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