Ivd isovaleryl coenzyme A dehydrogenase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ivdprovided by MGI
Official Full Name: isovaleryl coenzyme A dehydrogenaseprovided by MGI
Primary source: MGI:MGI:1929242
See related: Ensembl:ENSMUSG00000027332 AllianceGenome:MGI:1929242
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1300016K07Rik; 6720455E18Rik
Summary: Predicted to enable identical protein binding activity and isovaleryl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase and leucine catabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; ear; genitourinary system; and respiratory system. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and isovaleric acidemia. Orthologous to human IVD (isovaleryl-CoA dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 99.3), heart adult (RPKM 88.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E5; 2 59.64 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (118692475..118713388)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (118861959..118882909)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI463340 (e-PCR)
- UniSTS:159003

NoName (e-PCR)
- UniSTS:234494

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables isovaleryl-CoA dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables isovaleryl-CoA dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info
enables short-chain fatty acyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-leucine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-leucine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in branched-chain amino acid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: isovaleryl-CoA dehydrogenase, mitochondrial

Names: butyryl-CoA dehydrogenase

NP_001403148.1

EC 1.3.8.1

EC 1.3.8.4

NP_001403149.1

EC 1.3.8.1

EC 1.3.8.4

NP_062800.1

EC 1.3.8.1

EC 1.3.8.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001416219.1 → NP_001403148.1 isovaleryl-CoA dehydrogenase, mitochondrial isoform 2

Status: VALIDATED

Source sequence(s)

AL772255
NM_001416220.1 → NP_001403149.1 isovaleryl-CoA dehydrogenase, mitochondrial isoform 3

Status: VALIDATED

Source sequence(s)

AL772255
NM_019826.5 → NP_062800.1 isovaleryl-CoA dehydrogenase, mitochondrial isoform 1 precursor

See identical proteins and their annotated locations for NP_062800.1

Status: VALIDATED

Source sequence(s)

AL772255

Consensus CDS

CCDS16586.1

UniProtKB/Swiss-Prot

Q9CYI3, Q9DBD7, Q9JHI5

Related

ENSMUSP00000028807.6, ENSMUST00000028807.6

Conserved Domains (2) summary

cd01156
Location:42 → 421

IVD; Isovaleryl-CoA dehydrogenase

PLN02519
Location:43 → 417

PLN02519; isovaleryl-CoA dehydrogenase