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    gpnmb glycoprotein (transmembrane) nmb [ Danio rerio (zebrafish) ]

    Gene ID: 563348, updated on 11-Apr-2024

    Summary

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    Official Symbol
    gpnmbprovided by ZNC
    Official Full Name
    glycoprotein (transmembrane) nmbprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060503-106
    See related
    Ensembl:ENSDARG00000062688 AllianceGenome:ZFIN:ZDB-GENE-060503-106
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-155k24.6
    Summary
    Predicted to enable integrin binding activity. Predicted to be involved in cell adhesion. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in primary localized cutaneous amyloidosis 3. Orthologous to human GPNMB (glycoprotein nmb). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 19
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (20248695..20270191, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (20666946..20685853, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene transformer 2 alpha homolog Neighboring gene insulin-like growth factor 2 mRNA binding protein 3 Neighboring gene oxidoreductase NAD-binding domain containing 1 Neighboring gene raftlin, lipid raft linker 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E-mediated pyroptosis. Li JY, et al. J Biol Chem, 2020 Jan 24. PMID 31852739, Free PMC Article
    2. Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish. Lelieveld LT, et al. J Lipid Res, 2022 May. PMID 35315333, Free PMC Article
    3. The gene regulatory basis of genetic compensation during neural crest induction. Dooley CM, et al. PLoS Genet, 2019 Jun. PMID 31199790, Free PMC Article
    4. Thyroid hormone regulates distinct paths to maturation in pigment cell lineages. Saunders LM, et al. Elife, 2019 May 29. PMID 31140974, Free PMC Article
    5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane glycoprotein NMB

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      20248695..20270191 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009294247.3 → XP_009292522.1  transmembrane glycoprotein NMB isoform X1

      UniProtKB/TrEMBL
      A0A8M3B3J0, E7F7J7
      Related
      ENSDARP00000085316.5, ENSDART00000090883.6
      Conserved Domains (1) summary
      pfam00801
      Location:250 → 317
      PKD; PKD domain

    2. XM_686712.9 → XP_691804.2  transmembrane glycoprotein NMB isoform X2

      UniProtKB/TrEMBL
      A0A8N7TB94
      Related
      ENSDARP00000119730.2, ENSDART00000144891.3
      Conserved Domains (1) summary
      pfam00801
      Location:244 → 311
      PKD; PKD domain
    Nucleotide Protein Strain
    Heading Accession and Version

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