U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    trpv1 transient receptor potential cation channel, subfamily V, member 1 [ Danio rerio (zebrafish) ]

    Gene ID: 561195, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    trpv1provided by ZNC
    Official Full Name
    transient receptor potential cation channel, subfamily V, member 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030912-8
    See related
    Ensembl:ENSDARG00000059883 AllianceGenome:ZFIN:ZDB-GENE-030912-8
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-9e15.2
    Summary
    Predicted to enable calcium channel activity. Acts upstream of or within response to heat and thermosensory behavior. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including epithelium; keratinocyte; nervous system; pleuroperitoneal region; and sperm. Human ortholog(s) of this gene implicated in colorectal cancer; congenital stationary night blindness; keratosis (multiple); migraine (multiple); and schizophrenia. Orthologous to several human genes including TRPV1 (transient receptor potential cation channel subfamily V member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 5
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (42135265..42156100)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (41535131..41555937)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 5 Neighboring gene ER membrane protein complex subunit 6 Neighboring gene sedoheptulokinase Neighboring gene family with sequence similarity 222 member Ba Neighboring gene Era-like 12S mitochondrial rRNA chaperone 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Oleanolic acid promotes orofacial antinociception in adult zebrafish (Danio rerio) through TRPV1 receptors. Soares ICR, et al. Chem Biol Interact, 2019 Feb 1. PMID 30496739
    2. Localization of vanilloid receptor 1 (TRPV1/VR1)-like immunoreactivity in goldfish and zebrafish retinas: restriction to photoreceptor synaptic ribbons. Zimov S, et al. J Neurocytol, 2004 Jul. PMID 15520529
    3. Sperm motility modulated by Trpv1 regulates zebrafish fertilization. Chen Y, et al. Theriogenology, 2020 Jul 15. PMID 32251938
    4. The zebrafish ortholog of TRPV1 is required for heat-induced locomotion. Gau P, et al. J Neurosci, 2013 Mar 20. PMID 23516290, Free PMC Article
    5. The diversity in sensitivity of TRPA1 and TRPV1 of various animals to polyphenols. Takahashi S, et al. Biomed Res, 2021. PMID 33840685

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sperm motility modulated by Trpv1 regulates zebrafish fertilization.
      Title: Sperm motility modulated by Trpv1 regulates zebrafish fertilization.
    2. Results demonstrate that cell motility and Ca(2+)i activity are affected by pharmacological agents that target TRPV1, indicating a novel role for this channel during cell migration.
      Title: Epidermal keratinocyte polarity and motility require Ca²⁺ influx through TRPV1.
    3. Using knock-down studies, we also show that TRPV1 is required for normal heat-induced locomotion.
      Title: The zebrafish ortholog of TRPV1 is required for heat-induced locomotion.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within thermosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in dendritic spine membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    transient receptor potential cation channel subfamily V member 1
    Names
    TRPV1/2
    transient receptor potential V1 channel

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126399.1 → NP_001119871.1  transient receptor potential cation channel subfamily V member 1

      Status: PROVISIONAL

      Source sequence(s)
      BX571977
      UniProtKB/TrEMBL
      A0A8M1NJ94, B0S711
      Related
      ENSDARP00000115992.1, ENSDART00000140743.2
      Conserved Domains (4) summary
      cd00204
      Location:161 → 314
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00520
      Location:479 → 683
      Ion_trans; Ion transport protein
      pfam12796
      Location:81 → 192
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:163 → 193
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      42135265..42156100
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165327.4 → XP_005165384.1  transient receptor potential cation channel subfamily V member 1 isoform X1

      See identical proteins and their annotated locations for XP_005165384.1

      UniProtKB/TrEMBL
      A0A8M2BCL3, B6RTA2
      Related
      ENSDARP00000133320.1, ENSDART00000172201.2
      Conserved Domains (4) summary
      cd00204
      Location:165 → 318
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00520
      Location:485 → 689
      Ion_trans; Ion transport protein
      pfam12796
      Location:85 → 196
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:167 → 197
      ANK; ANK repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.