U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase [ Danio rerio (zebrafish) ]

    Gene ID: 560667, updated on 27-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    mtrrprovided by ZNC
    Official Full Name
    5-methyltetrahydrofolate-homocysteine methyltransferase reductaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-101115-3
    See related
    Ensembl:ENSDARG00000045398 AllianceGenome:ZFIN:ZDB-GENE-101115-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable FMN binding activity; [methionine synthase] reductase activity; and flavin adenine dinucleotide binding activity. Predicted to be involved in homocysteine metabolic process and methionine biosynthetic process. Predicted to be active in cytosol. Used to study visceral heterotaxy. Human ortholog(s) of this gene implicated in several diseases, including endocrine gland cancer (multiple); heart disease (multiple); hematologic cancer (multiple); homocystinuria; and homocystinuria-megaloblastic anemia cblE type. Orthologous to human MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See mtrr in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (16855750..16905018, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (16711331..16760599, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110437797 Neighboring gene sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A Neighboring gene transfer RNA threonine (anticodon AGU) Neighboring gene chaperonin containing TCP1, subunit 5 (epsilon) Neighboring gene carboxymethylenebutenolidase homolog (Pseudomonas)

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis. Burkhalter MD, et al. J Clin Invest, 2019 May 16. PMID 31094706, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables FMN binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables [methionine synthase] reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in homocysteine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methionine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    methionine synthase reductase
    XP_005162677.1
    XP_005162678.1
    XP_689157.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001386530.1 → NP_001373459.1  methionine synthase reductase

      Status: VALIDATED

      Source sequence(s)
      BX004771, BX469922
      UniProtKB/TrEMBL
      A0A8N7TD34, F1RE28
      Conserved Domains (2) summary
      cd06203
      Location:274 → 696
      methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...
      pfam00258
      Location:11 → 147
      Flavodoxin_1

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      16855750..16905018 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005162620.3 → XP_005162677.1  methionine synthase reductase isoform X2

      UniProtKB/TrEMBL
      A0A8M2B9H1
      Conserved Domains (3) summary
      cd06203
      Location:274 → 695
      methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...
      COG0369
      Location:4 → 695
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:11 → 147
      Flavodoxin_1; Flavodoxin

    2. XM_684065.4 → XP_689157.2  methionine synthase reductase isoform X1

      UniProtKB/TrEMBL
      F1RE28
      Related
      ENSDARP00000066758.4, ENSDART00000066759.6
      Conserved Domains (2) summary
      cd06203
      Location:274 → 696
      methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...
      pfam00258
      Location:11 → 147
      Flavodoxin_1

    3. XM_005162621.4 → XP_005162678.1  methionine synthase reductase isoform X3

      UniProtKB/TrEMBL
      A0A0R4IZR6, A0A8M2B9T6
      Related
      ENSDARP00000141793.2, ENSDART00000165972.3
      Conserved Domains (3) summary
      cd06203
      Location:272 → 694
      methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...
      TIGR01931
      Location:3 → 694
      cysJ; sulfite reductase [NADPH] flavoprotein, alpha-component
      pfam00258
      Location:16 → 145
      Flavodoxin_1; Flavodoxin
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.