myo1d myosin 1D [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: myo1dprovided by ZNC
Official Full Name: myosin 1Dprovided by ZNC
Primary source: ZFIN:ZDB-GENE-130531-15
See related: Ensembl:ENSDARG00000036863 AllianceGenome:ZFIN:ZDB-GENE-130531-15
Gene type: protein coding
RefSeq status: INFERRED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch211-94l19.4
Summary: Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within Kupffer's vesicle development. Predicted to be active in several cellular components, including actin cytoskeleton; microvillus; and vesicle. Is expressed in notochord and tail bud. Orthologous to human MYO1D (myosin ID). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (28377745..28537597, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (28262843..28422693, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study reveal that an unconventional myosin, myo1d is required for proper Kupffer's vesicle lumen formation in zebrafish.
Title: Vertebrate myosin 1d regulates left-right organizer morphogenesis and laterality.
Data show that functional interactions between myosin-Id (Myo1D) and planar cell polarity (PCP) are central to the establishment of animal left-right (LR) asymmetry.
Title: Myosin1D is an evolutionarily conserved regulator of animal left-right asymmetry.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Kupffer's vesicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of liver left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of pancreatic left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cilium movement involved in determination of left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart jogging	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: unconventional myosin-Id

Names: myosin ID; myosin1D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001423964.1 → NP_001410893.1 unconventional myosin-Id

Status: INFERRED

Source sequence(s)

CR391936, CT033798, CT033800

UniProtKB/Swiss-Prot

E7F9L8

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

28377745..28537597 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_682916.8 → XP_688008.5 unconventional myosin-Id

UniProtKB/TrEMBL

E7F9L8

Related

ENSDARP00000067761.5, ENSDART00000067762.7

Conserved Domains (2) summary

cd01378
Location:23 → 682

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:803 → 994

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding