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    cntnap2a contactin associated protein 2a [ Danio rerio (zebrafish) ]

    Gene ID: 559157, updated on 11-Apr-2024

    Summary

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    Official Symbol
    cntnap2aprovided by ZNC
    Official Full Name
    contactin associated protein 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-120328-3
    See related
    Ensembl:ENSDARG00000058969 AllianceGenome:ZFIN:ZDB-GENE-120328-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Caspr2a
    Summary
    Predicted to act upstream of or within protein localization to juxtaparanode region of axon. Predicted to be located in membrane and paranodal junction. Predicted to be integral component of membrane. Is expressed in anterior lateral line ganglion and posterior lateral line ganglion. Human ortholog(s) of this gene implicated in several diseases, including Pitt-Hopkins syndrome; autism spectrum disorder (multiple); communication disorder (multiple); cortical dysplasia-focal epilepsy syndrome; and social phobia. Orthologous to human CNTNAP2 (contactin associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See cntnap2a in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (17420802..18179884, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (17276683..18035460, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene si:dkey-117j14.8 Neighboring gene cullin 1b Neighboring gene uncharacterized LOC110438351 Neighboring gene thiamin pyrophosphokinase 1 Neighboring gene zgc:112332 Neighboring gene SEC61 translocon subunit gamma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Sarm1 is dispensable for mechanosensory-motor transformations in zebrafish. Asgharsharghi A, et al. MicroPubl Biol, 2021 Mar 3. PMID 33688624, Free PMC Article
    2. The Transfer Characteristics of Hair Cells Encoding Mechanical Stimuli in the Lateral Line of Zebrafish. Pichler P, et al. J Neurosci, 2019 Jan 2. PMID 30413644, Free PMC Article
    3. High-resolution live imaging reveals axon-glia interactions during peripheral nerve injury and repair in zebrafish. Xiao Y, et al. Dis Model Mech, 2015 Jun. PMID 26035865, Free PMC Article
    4. Hair cell identity establishes labeled lines of directional mechanosensation. Lozano-Ortega M, et al. PLoS Biol, 2018 Jul. PMID 30024872, Free PMC Article
    5. Multispectral four-dimensional imaging reveals that evoked activity modulates peripheral arborization and the selection of plane-polarized targets by sensory neurons. Faucherre A, et al. Development, 2010 May. PMID 20430744

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in regulation of response to external stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in paranodal junction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    contactin-associated protein-like 2; contactin-associated protein-like 2a
    Names
    contactin associated protein like 2a
    zmp:0000000672

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281991.1 → NP_001268920.1  contactin-associated protein-like 2a precursor

      See identical proteins and their annotated locations for NP_001268920.1

      Status: PROVISIONAL

      Source sequence(s)
      HQ880436
      UniProtKB/TrEMBL
      A0A8M1P5D4, L7NKH5
      Related
      ENSDARP00000146773.1, ENSDART00000186112.1
      Conserved Domains (6) summary
      smart00294
      Location:1267 → 1285
      4.1m; putative band 4.1 homologues' binding motif
      smart00231
      Location:31 → 178
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00054
      Location:547 → 582
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00057
      Location:46 → 177
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:792 → 935
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam02210
      Location:213 → 342
      Laminin_G_2; Laminin G domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      17420802..18179884 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009297353.3 → XP_009295628.1  contactin-associated protein-like 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B6M0
      Related
      ENSDARP00000154768.1, ENSDART00000185619.1
      Conserved Domains (6) summary
      smart00294
      Location:1277 → 1295
      4.1m; putative band 4.1 homologues' binding motif
      smart00231
      Location:31 → 178
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00054
      Location:547 → 582
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00057
      Location:46 → 177
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:792 → 945
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam02210
      Location:213 → 342
      Laminin_G_2; Laminin G domain
    Nucleotide Protein
    Heading Accession and Version

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