trim3b tripartite motif containing 3b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: trim3bprovided by ZNC
Official Full Name: tripartite motif containing 3bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070112-1132
See related: Ensembl:ENSDARG00000005397 AllianceGenome:ZFIN:ZDB-GENE-070112-1132
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:153967
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein polyubiquitination. Predicted to be located in cytoplasm. Orthologous to human TRIM3 (tripartite motif containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (26130856..26188866, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (26169143..26227153, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables translation repressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: NHL repeat-containing protein 3; tripartite motif-containing protein 3b

NP_001073637.1

EC 2.3.2.27

XP_005155434.1

EC 2.3.2.27

XP_005155435.1

EC 2.3.2.27

XP_009303590.1

EC 2.3.2.27

XP_021334851.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080168.1 → NP_001073637.1 tripartite motif-containing protein 3b

See identical proteins and their annotated locations for NP_001073637.1

Status: PROVISIONAL

Source sequence(s)

BC129039

UniProtKB/TrEMBL

A1L1F8

Related

ENSDARP00000117680.1, ENSDART00000136472.3

Conserved Domains (7) summary

smart00502
Location:162 → 287

BBC; B-Box C-terminal domain

smart00336
Location:114 → 155

BBOX; B-Box-type zinc finger

smart00557
Location:329 → 423

IG_FLMN; Filamin-type immunoglobulin domains

COG3391
Location:504 → 739

YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]

cd00162
Location:23 → 66

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd14960
Location:475 → 748

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

pfam00630
Location:329 → 420

Filamin; Filamin/ABP280 repeat

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007121.7 Reference GRCz11 Primary Assembly

Range

26130856..26188866 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009305315.3 → XP_009303590.1 NHL repeat-containing protein 3 isoform X1

See identical proteins and their annotated locations for XP_009303590.1

UniProtKB/TrEMBL

A0A286YB14, A0A8M2B1X4

Conserved Domains (5) summary

smart00502
Location:166 → 291

BBC; B-Box C-terminal domain

smart00336
Location:118 → 159

BBOX; B-Box-type zinc finger

cd14960
Location:479 → 772

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

pfam00630
Location:333 → 424

Filamin; Filamin/ABP280 repeat

cd16768
Location:24 → 68

RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)
XM_005155378.4 → XP_005155435.1 NHL repeat-containing protein 3 isoform X1

See identical proteins and their annotated locations for XP_005155435.1

UniProtKB/TrEMBL

A0A286YB14, A0A8M2B1X4

Related

ENSDARP00000144354.2, ENSDART00000174797.2

Conserved Domains (5) summary

smart00502
Location:166 → 291

BBC; B-Box C-terminal domain

smart00336
Location:118 → 159

BBOX; B-Box-type zinc finger

cd14960
Location:479 → 772

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

pfam00630
Location:333 → 424

Filamin; Filamin/ABP280 repeat

cd16768
Location:24 → 68

RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)
XM_005155377.4 → XP_005155434.1 NHL repeat-containing protein 3 isoform X1

See identical proteins and their annotated locations for XP_005155434.1

UniProtKB/TrEMBL

A0A286YB14, A0A8M2B1X4

Conserved Domains (5) summary

smart00502
Location:166 → 291

BBC; B-Box C-terminal domain

smart00336
Location:118 → 159

BBOX; B-Box-type zinc finger

cd14960
Location:479 → 772

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

pfam00630
Location:333 → 424

Filamin; Filamin/ABP280 repeat

cd16768
Location:24 → 68

RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)
XM_021479176.1 → XP_021334851.1 NHL repeat-containing protein 3 isoform X1

UniProtKB/TrEMBL

A0A286YB14, A0A8M2B1X4

Conserved Domains (5) summary

smart00502
Location:166 → 291

BBC; B-Box C-terminal domain

smart00336
Location:118 → 159

BBOX; B-Box-type zinc finger

cd14960
Location:479 → 772

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

pfam00630
Location:333 → 424

Filamin; Filamin/ABP280 repeat

cd16768
Location:24 → 68

RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)