hs1bp3 HCLS1 binding protein 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hs1bp3provided by ZNC
Official Full Name: HCLS1 binding protein 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-131121-391
See related: Ensembl:ENSDARG00000034222 AllianceGenome:ZFIN:ZDB-GENE-131121-391
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch1073-80i24.2
Summary: Predicted to enable phosphatidylinositol binding activity. Acts upstream of or within negative regulation of autophagy. Human ortholog(s) of this gene implicated in essential tremor 2. Orthologous to human HS1BP3 (HCLS1 binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (48947770..48961698)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (48911643..48925571)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HS1BP3 is localized to ATG16L1- and ATG9-positive autophagosome precursors and we show that HS1BP3 binds phosphatidic acid (PA) through its PX domain.
Title: HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: HCLS1-binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256221.1 → NP_001243150.1 HCLS1-binding protein 3

Status: PROVISIONAL

Source sequence(s)

BC076062

UniProtKB/TrEMBL

A0A8M1P2H7, F6PCK0, Q6DHB3

Related

ENSDARP00000043665.5, ENSDART00000043666.6

Conserved Domains (1) summary

cd06868
Location:17 → 136

PX_HS1BP3; The phosphoinositide binding Phox Homology domain of HS1BP3