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    Ppt2 palmitoyl-protein thioesterase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54398, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ppt2provided by RGD
    Official Full Name
    palmitoyl-protein thioesterase 2provided by RGD
    Primary source
    RGD:620375
    See related
    Ensembl:ENSRNOG00000000435 AllianceGenome:RGD:620375
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable palmitoyl hydrolase activity and thiolester hydrolase activity. Predicted to be involved in macromolecule depalmitoylation. Predicted to be active in lysosome. Orthologous to human PPT2 (palmitoyl-protein thioesterase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 61.8), Kidney (RPKM 54.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    20p12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4117088..4137382)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4112520..4132774)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4381455..4401638, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098978 Neighboring gene activating transcription factor 6 beta Neighboring gene FKBP prolyl isomerase like Neighboring gene proline-rich transmembrane protein 1 Neighboring gene EGF-like-domain, multiple 8 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 1 Neighboring gene ring finger protein 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Disruption of PPT2 in mice causes an unusual lysosomal storage disorder with neurovisceral features. Gupta P, et al. Proc Natl Acad Sci U S A, 2003 Oct 14. PMID 14528005, Free PMC Article
    2. Characterization of a human MHC class III region gene product with S-thioesterase activity. Aguado B, et al. Biochem J, 1999 Aug 1. PMID 10417332, Free PMC Article
    3. Molecular cloning and expression of palmitoyl-protein thioesterase 2 (PPT2), a homolog of lysosomal palmitoyl-protein thioesterase with a distinct substrate specificity. Soyombo AA, et al. J Biol Chem, 1997 Oct 24. PMID 9341199
    4. Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice. Gupta P, et al. Proc Natl Acad Sci U S A, 2001 Nov 20. PMID 11717424, Free PMC Article
    5. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, et al. Genome Res, 2004 Apr. PMID 15060004, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables palmitoyl hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyl hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables thiolester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in macromolecule depalmitoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lysosomal thioesterase PPT2
    NP_062240.1
    XP_006256079.2
    XP_006256081.1
    XP_006256082.1
    XP_006256084.1
    XP_006256085.1
    XP_008770984.1
    XP_038954969.1
    XP_038954973.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019367.2 → NP_062240.1  lysosomal thioesterase PPT2 precursor

      See identical proteins and their annotated locations for NP_062240.1

      Status: VALIDATED

      Source sequence(s)
      BC062023, CB736242
      UniProtKB/Swiss-Prot
      O70489, O88500
      UniProtKB/TrEMBL
      A0A8L2R8R8, A6KTI0
      Related
      ENSRNOP00000000497.5, ENSRNOT00000000497.8
      Conserved Domains (1) summary
      pfam02089
      Location:38 → 283
      Palm_thioest; Palmitoyl protein thioesterase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      4117088..4137382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256017.4 → XP_006256079.2  lysosomal thioesterase PPT2 isoform X1

      UniProtKB/Swiss-Prot
      O70489, O88500
      UniProtKB/TrEMBL
      A0A8L2R8R8, A6KTI0
      Conserved Domains (1) summary
      pfam02089
      Location:38 → 283
      Palm_thioest; Palmitoyl protein thioesterase

    2. XM_039099041.2 → XP_038954969.1  lysosomal thioesterase PPT2 isoform X2

      Conserved Domains (1) summary
      pfam02089
      Location:62 → 205
      Palm_thioest; Palmitoyl protein thioesterase

    3. XM_006256023.4 → XP_006256085.1  lysosomal thioesterase PPT2 isoform X1

      See identical proteins and their annotated locations for XP_006256085.1

      UniProtKB/Swiss-Prot
      O70489, O88500
      UniProtKB/TrEMBL
      A0A8L2R8R8, A6KTI0
      Conserved Domains (1) summary
      pfam02089
      Location:38 → 283
      Palm_thioest; Palmitoyl protein thioesterase

    4. XM_006256020.5 → XP_006256082.1  lysosomal thioesterase PPT2 isoform X1

      See identical proteins and their annotated locations for XP_006256082.1

      UniProtKB/Swiss-Prot
      O70489, O88500
      UniProtKB/TrEMBL
      A0A8L2R8R8, A6KTI0
      Conserved Domains (1) summary
      pfam02089
      Location:38 → 283
      Palm_thioest; Palmitoyl protein thioesterase

    5. XM_006256022.5 → XP_006256084.1  lysosomal thioesterase PPT2 isoform X1

      See identical proteins and their annotated locations for XP_006256084.1

      UniProtKB/Swiss-Prot
      O70489, O88500
      UniProtKB/TrEMBL
      A0A8L2R8R8, A6KTI0
      Related
      ENSRNOP00000074361.2
      Conserved Domains (1) summary
      pfam02089
      Location:38 → 283
      Palm_thioest; Palmitoyl protein thioesterase

    6. XM_006256019.4 → XP_006256081.1  lysosomal thioesterase PPT2 isoform X1

      See identical proteins and their annotated locations for XP_006256081.1

      UniProtKB/Swiss-Prot
      O70489, O88500
      UniProtKB/TrEMBL
      A0A8L2R8R8, A6KTI0
      Conserved Domains (1) summary
      pfam02089
      Location:38 → 283
      Palm_thioest; Palmitoyl protein thioesterase

    7. XM_008772762.4 → XP_008770984.1  lysosomal thioesterase PPT2 isoform X1

      See identical proteins and their annotated locations for XP_008770984.1

      UniProtKB/Swiss-Prot
      O70489, O88500
      UniProtKB/TrEMBL
      A0A8L2R8R8, A6KTI0
      Conserved Domains (1) summary
      pfam02089
      Location:38 → 283
      Palm_thioest; Palmitoyl protein thioesterase

    8. XM_039099045.2 → XP_038954973.1  lysosomal thioesterase PPT2 isoform X3

      Conserved Domains (1) summary
      pfam02089
      Location:27 → 182
      Palm_thioest; Palmitoyl protein thioesterase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70489.1 GenPept UniProtKB/Swiss-Prot:O70489

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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