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    Copg2 coatomer protein complex, subunit gamma 2 [ Mus musculus (house mouse) ]

    Gene ID: 54160, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Copg2provided by MGI
    Official Full Name
    coatomer protein complex, subunit gamma 2provided by MGI
    Primary source
    MGI:MGI:1858683
    See related
    Ensembl:ENSMUSG00000025607 AllianceGenome:MGI:1858683
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    gamma-2-COP
    Summary
    Predicted to enable structural molecule activity. Predicted to be involved in Golgi vesicle transport; organelle transport along microtubule; and protein secretion. Predicted to act upstream of or within protein transport. Located in COPI-coated vesicle; Golgi membrane; and growth cone. Is expressed in brain and early conceptus. Orthologous to human COPG2 (COPI coat complex subunit gamma 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in limb E14.5 (RPKM 91.4), CNS E11.5 (RPKM 47.5) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 A3.3; 6 12.54 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (30747552..30873712, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (30747554..30896815, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene centrosomal protein 41 Neighboring gene predicted gene 13782 Neighboring gene STARR-positive B cell enhancer mm9_chr6:30643637-30643938 Neighboring gene STARR-seq mESC enhancer starr_15474 Neighboring gene mesoderm specific transcript Neighboring gene microRNA 335 Neighboring gene coatomer protein complex, subunit gamma 2, opposite strand 2 Neighboring gene RIKEN cDNA 4930412F09 gene Neighboring gene predicted gene, 38781 Neighboring gene testis specific gene A13 Neighboring gene Kruppel-like transcription factor 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Allele-specific methylation at the promoter-associated CpG island of mouse Copg2. Yun J, et al. Mamm Genome, 2003 Jun. PMID 12879359
    2. Phylogenetic relationships of the seven coat protein subunits of the coatomer complex, and comparative sequence analysis of murine xenin and proxenin. Chow VT, et al. Biochem Genet, 2001 Jun. PMID 11530856
    3. The COPI vesicle complex binds and moves with survival motor neuron within axons. Peter CJ, et al. Hum Mol Genet, 2011 May 1. PMID 21300694, Free PMC Article
    4. Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1). Lee YJ, et al. FEBS Lett, 2000 Apr 28. PMID 10788617
    5. Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability. Kuliyev E, et al. J Neurosci, 2018 Mar 7. PMID 29437892, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Copg2 gene, closely linked to Mest/Peg1 gene on chr 6, is paternally imprinted.
      Title: Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organelle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPI vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPI vesicle coat ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in COPI-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coatomer subunit gamma-2
    Names
    gamma-2-coat protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411182.1 → NP_001398111.1  coatomer subunit gamma-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC183098, AEKQ02054615
      Related
      ENSMUSP00000126726.4, ENSMUST00000166192.7

    2. NM_001411184.1 → NP_001398113.1  coatomer subunit gamma-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC183098
      Related
      ENSMUST00000131256.8

    3. NM_017478.4 → NP_059506.1  coatomer subunit gamma-2 isoform 1

      See identical proteins and their annotated locations for NP_059506.1

      Status: VALIDATED

      Source sequence(s)
      AC183098, AEKQ02054615
      Consensus CDS
      CCDS85027.1
      UniProtKB/Swiss-Prot
      A6H6J5, Q3TQD5, Q3UEL6, Q8C2J6, Q9QXK3
      Related
      ENSMUSP00000038368.7, ENSMUST00000048774.13
      Conserved Domains (5) summary
      COG5240
      Location:7 → 866
      SEC21; Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]
      pfam08752
      Location:613 → 756
      COP-gamma_platf; Coatomer gamma subunit appendage platform subdomain
      pfam11701
      Location:325 → 497
      UNC45-central; Myosin-binding striated muscle assembly central
      pfam16381
      Location:758 → 870
      Coatomer_g_Cpla; Coatomer subunit gamma-1 C-terminal appendage platform
      sd00044
      Location:398 → 423
      HEAT; HEAT repeat [structural motif]

    RNA

    1. NR_149738.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC183098, AEKQ02054615

    2. NR_177193.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC183098, AEKQ02054615

    3. NR_177194.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC183098, AEKQ02054615

    4. NR_183248.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC183098, AEKQ02054615

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      30747552..30873712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166293.1 → XP_036022186.1  coatomer subunit gamma-2 isoform X1

      Conserved Domains (2) summary
      COG5240
      Location:56 → 903
      SEC21; Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]
      sd00044
      Location:435 → 460
      HEAT; HEAT repeat [structural motif]

    RNA

    1. XR_001785154.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QXK3.1 GenPept UniProtKB/Swiss-Prot:Q9QXK3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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