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    MAPK10 mitogen-activated protein kinase 10 [ Bos taurus (cattle) ]

    Gene ID: 537631, updated on 3-Apr-2024

    Summary

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    Official Symbol
    MAPK10provided by VGNC
    Official Full Name
    mitogen-activated protein kinase 10provided by VGNC
    Primary source
    VGNC:VGNC:31213
    See related
    BGD:BT11390; Ensembl:ENSBTAG00000020048
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Summary
    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 6
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (100907861..101530086, complement)

    Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112447118 Neighboring gene WD repeat and FYVE domain containing 3 Neighboring gene Rho GTPase activating protein 24 Neighboring gene ragulator complex protein LAMTOR5-like Neighboring gene SUMO-conjugating enzyme UBC9-like Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene disks large-associated protein 4-like Neighboring gene protein tyrosine phosphatase non-receptor type 13 Neighboring gene solute carrier family 10 member 6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of arrestin-3-specific residues necessary for JNK3 kinase activation. Seo J, et al. J Biol Chem, 2011 Aug 12. PMID 21715332, Free PMC Article
    2. SDF-1alpha stimulates JNK3 activity via eNOS-dependent nitrosylation of MKP7 to enhance endothelial migration. Pi X, et al. Proc Natl Acad Sci U S A, 2009 Apr 7. PMID 19307591, Free PMC Article
    3. Evidence of efficient stop codon readthrough in four mammalian genes. Loughran G, et al. Nucleic Acids Res, 2014 Aug. PMID 25013167, Free PMC Article
    4. Misreading of termination codons in eukaryotes by natural nonsense suppressor tRNAs. Beier H, et al. Nucleic Acids Res, 2001 Dec 1. PMID 11726686, Free PMC Article
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. multiple residues on the non-receptor-binding side of arrestin-3 are crucial for JNK3 activation
      Title: Identification of arrestin-3-specific residues necessary for JNK3 kinase activation.
    2. identification of an intricate SDF-1alpha-induced signaling cascade that involves eNOS, JNK3, and MKP7and enhances endothelial migration
      Title: SDF-1alpha stimulates JNK3 activity via eNOS-dependent nitrosylation of MKP7 to enhance endothelial migration.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables JUN kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitogen-activated protein kinase 10
    NP_001077197.1
    NP_001305129.1
    NP_001305130.1
    XP_005208248.1
    XP_005208252.1
    XP_005208254.1
    XP_010804592.1
    XP_010804594.1
    XP_024849113.1
    XP_024849114.1
    XP_059743570.1
    XP_059743571.1
    XP_059743572.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083728.3 → NP_001077197.1  mitogen-activated protein kinase 10 isoform 2

      See identical proteins and their annotated locations for NP_001077197.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate acceptor splice site in the 5' region, which results in translation initiation from an in-frame, downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      BC123518, DV829805, EV784689
      UniProtKB/TrEMBL
      A4FV00, F1N456, Q05B47
      Related
      ENSBTAP00000026712.5, ENSBTAT00000026712.6
      Conserved Domains (1) summary
      cd07850
      Location:25 → 360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    2. NM_001318200.1 → NP_001305129.1  mitogen-activated protein kinase 10 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1, also known as JNK3 alpha2) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (1).
      Source sequence(s)
      BC123518, DV829805, EH134072, EV784689
      UniProtKB/TrEMBL
      Q05B47
      Conserved Domains (1) summary
      cd07850
      Location:63 → 398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    3. NM_001318201.1 → NP_001305130.1  mitogen-activated protein kinase 10 isoform 1x

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1, also known as JNK3 alpha2) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
      Source sequence(s)
      BC123518, DV829805, EH134072, EV784689
      UniProtKB/TrEMBL
      Q05B47
      Conserved Domains (2) summary
      smart00220
      Location:64 → 359
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07850
      Location:63 → 398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      100907861..101530086 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059887589.1 → XP_059743572.1  mitogen-activated protein kinase 10 isoform X2

    2. XM_005208191.5 → XP_005208248.1  mitogen-activated protein kinase 10 isoform X2

      See identical proteins and their annotated locations for XP_005208248.1

      UniProtKB/TrEMBL
      Q05B47
      Conserved Domains (1) summary
      cd07850
      Location:63 → 398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    3. XM_059887587.1 → XP_059743570.1  mitogen-activated protein kinase 10 isoform X2

    4. XM_024993345.2 → XP_024849113.1  mitogen-activated protein kinase 10 isoform X2

      UniProtKB/TrEMBL
      Q05B47
      Related
      ENSBTAP00000059818.2, ENSBTAT00000084303.2
      Conserved Domains (1) summary
      cd07850
      Location:63 → 398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    5. XM_010806290.4 → XP_010804592.1  mitogen-activated protein kinase 10 isoform X1

      See identical proteins and their annotated locations for XP_010804592.1

      UniProtKB/TrEMBL
      Q05B47
      Related
      ENSBTAP00000101844.1, ENSBTAT00000131183.1
      Conserved Domains (1) summary
      cd07850
      Location:63 → 398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    6. XM_010806292.4 → XP_010804594.1  mitogen-activated protein kinase 10 isoform X4

      See identical proteins and their annotated locations for XP_010804594.1

      UniProtKB/TrEMBL
      Q05B47
      Conserved Domains (1) summary
      cd07850
      Location:63 → 398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    7. XM_024993346.2 → XP_024849114.1  mitogen-activated protein kinase 10 isoform X3

      UniProtKB/TrEMBL
      A4FV00, F1N456, Q05B47
      Conserved Domains (1) summary
      cd07850
      Location:25 → 360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    8. XM_005208195.5 → XP_005208252.1  mitogen-activated protein kinase 10 isoform X3

      See identical proteins and their annotated locations for XP_005208252.1

      UniProtKB/TrEMBL
      A4FV00, F1N456, Q05B47
      Conserved Domains (1) summary
      cd07850
      Location:25 → 360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    9. XM_059887588.1 → XP_059743571.1  mitogen-activated protein kinase 10 isoform X2

    10. XM_005208197.5 → XP_005208254.1  mitogen-activated protein kinase 10 isoform X3

      See identical proteins and their annotated locations for XP_005208254.1

      UniProtKB/TrEMBL
      A4FV00, F1N456, Q05B47
      Conserved Domains (1) summary
      cd07850
      Location:25 → 360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    Nucleotide Protein Strain
    Heading Accession and Version

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