APC2 APC regulator of WNT signaling pathway 2 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: APC2provided by VGNC
Official Full Name: APC regulator of WNT signaling pathway 2provided by VGNC
Primary source: VGNC:VGNC:26006
See related: BGD:BT18620; Ensembl:ENSBTAG00000015433
Gene type: protein coding
RefSeq status: MODEL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	7	NC_037334.1 (43851850..43878127)

Chromosome 7 - NC_037334.1 Genomic Context describing neighboring genes

Genomic Sequence:: NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables beta-catenin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables gamma-catenin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables microtubule binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell fate specification	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of microtubule depolymerization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in pattern specification process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of beta-catenin destruction complex	IEA Inferred from Electronic Annotation more info	PubMed
part_of catenin complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasmic microtubule	IEA Inferred from Electronic Annotation more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain

XM_002689175.7 → XP_002689221.6 adenomatous polyposis coli protein 2 isoform X1

UniProtKB/TrEMBL

E1BI79
XM_005209327.5 → XP_005209384.4 adenomatous polyposis coli protein 2 isoform X2
XM_005209328.5 → XP_005209385.2 adenomatous polyposis coli protein 2 isoform X3

UniProtKB/TrEMBL

A0A3Q1LRP9

Related

ENSBTAP00000057735.1, ENSBTAT00000077910.2

Conserved Domains (11) summary

smart00185
Location:614 → 654

ARM; Armadillo/beta-catenin-like repeats

pfam00514
Location:656 → 696

Arm; Armadillo/beta-catenin-like repeat

pfam16689
Location:6 → 57

APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain

sd00043
Location:527 → 560

ARM; armadillo repeat [structural motif]

pfam05923
Location:1238 → 1259

APC_r; APC repeat

pfam05924
Location:1590 → 1611

SAMP; SAMP Motif

pfam05937
Location:2209 → 2250

EB1_binding; EB-1 Binding Domain

pfam05956
Location:1752 → 2084

APC_basic; APC basic domain

pfam11414
Location:124 → 205

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:697 → 956

Arm_APC_u3; Armadillo-associated region on APC

cl28033
Location:1985 → 2223

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region