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    EHMT2 euchromatic histone lysine methyltransferase 2 [ Bos taurus (cattle) ]

    Gene ID: 514062, updated on 3-Apr-2024

    Summary

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    Official Symbol
    EHMT2provided by VGNC
    Official Full Name
    euchromatic histone lysine methyltransferase 2provided by VGNC
    Primary source
    VGNC:VGNC:50609
    See related
    Ensembl:ENSBTAG00000005676
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    BAT8
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 23
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (27467183..27480387)

    Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene complement C2 Neighboring gene zinc finger and BTB domain containing 12 Neighboring gene solute carrier family 44 member 4 Neighboring gene neuraminidase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells. Singh N, et al. J Interferon Cytokine Res, 2016 Jan. PMID 26418342, Free PMC Article
    2. YAC/BAC contig spanning the MHC class III region of cattle. Gelhaus A, et al. Cytogenet Genome Res, 2006. PMID 16974083
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The data confirm the involvement of EHMT2 in the epigenetic regulation of IFN-b and demonstrate the activation of a general antiviral state after EHMT2 inhibition.
      Title: Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables histone methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables p53 binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein-lysine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase EHMT2
    Names
    ankyrin repeat-containing protein
    euchromatic histone-lysine N-methyltransferase 2
    histone-lysine N-methyltransferase, H3 lysine-9 specific 3
    NP_001193192.2
    XP_005223693.1
    XP_024839340.2
    XP_024839341.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206263.2 → NP_001193192.2  histone-lysine N-methyltransferase EHMT2

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000023
      UniProtKB/TrEMBL
      A0A3Q1LSA6, F1N413
      Related
      ENSBTAP00000063225.1, ENSBTAT00000079107.2
      Conserved Domains (5) summary
      smart00468
      Location:924 → 1023
      PreSET; N-terminal to some SET domains
      smart00317
      Location:1039 → 1161
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd00204
      Location:687 → 806
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:786 → 816
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:655 → 716
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      27467183..27480387
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024983572.2 → XP_024839340.2  histone-lysine N-methyltransferase EHMT2 isoform X1

    2. XM_024983573.2 → XP_024839341.2  histone-lysine N-methyltransferase EHMT2 isoform X2

    3. XM_005223636.4 → XP_005223693.1  histone-lysine N-methyltransferase EHMT2 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1M4W7
      Related
      ENSBTAP00000065284.2, ENSBTAT00000067355.2
      Conserved Domains (6) summary
      smart00468
      Location:890 → 989
      PreSET; N-terminal to some SET domains
      smart00317
      Location:1005 → 1127
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd00204
      Location:653 → 772
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:689 → 782
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:752 → 782
      ANK; ANK repeat [structural motif]
      cl02529
      Location:621 → 672
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    Nucleotide Protein Strain
    Heading Accession and Version

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