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    metap1 methionyl aminopeptidase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 503783, updated on 27-Mar-2024

    Summary

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    Official Symbol
    metap1provided by ZNC
    Official Full Name
    methionyl aminopeptidase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050626-124
    See related
    Ensembl:ENSDARG00000033440 AllianceGenome:ZFIN:ZDB-GENE-050626-124
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc84e12; im:7047238; wu:fc84e12; zgc:110093
    Summary
    Predicted to enable metal ion binding activity and metalloaminopeptidase activity. Predicted to be involved in protein initiator methionine removal. Predicted to act upstream of or within proteolysis. Predicted to be located in cytoplasm. Is expressed in immature eye; myotome; nervous system; pectoral fin; and pharyngeal arch. Orthologous to human METAP1 (methionyl aminopeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (12606821..12633241)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (12474269..12500765)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene glutamyl aminopeptidase Neighboring gene leucine-rich repeat, immunoglobulin-like and transmembrane domains 3b Neighboring gene alcohol dehydrogenase 8b Neighboring gene alcohol dehydrogenase 8a Neighboring gene family with sequence similarity 241 member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Epigenetic regulators Rbbp4 and Hdac1 are overexpressed in a zebrafish model of RB1 embryonal brain tumor, and are required for neural progenitor survival and proliferation. Schultz LE, et al. Dis Model Mech, 2018 Jun 15. PMID 29914980, Free PMC Article
    2. Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis. Weiss A, et al. Cell, 2022 Jun 9. PMID 35584702, Free PMC Article
    3. Genome-wide identification of novel long non-coding RNAs and their possible roles in hypoxic zebrafish brain. Banerjee B, et al. Genomics, 2021 Jan. PMID 33264657
    4. Alterations of protein profile in zebrafish liver cells exposed to methyl parathion: a membrane proteomics approach. Huang Q, et al. Chemosphere, 2012 Mar. PMID 22182705
    5. Methionine aminopeptidase 2 is required for HSC initiation and proliferation. Ma AC, et al. Blood, 2011 Nov 17. PMID 21937698, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis.
      Title: Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables initiator methionyl aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular zinc ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    methionine aminopeptidase 1
    NP_001020336.2
    XP_017214228.2
    XP_017214229.1
    XP_021336245.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025165.2 → NP_001020336.2  methionine aminopeptidase 1

      Status: VALIDATED

      Source sequence(s)
      CR559943, EH501151
      UniProtKB/Swiss-Prot
      Q4QRK0, Q6DHD3
      UniProtKB/TrEMBL
      A0A0R4IWG3, A0A8M1N6S5, B8JIB1
      Related
      ENSDARP00000113818.1, ENSDART00000140096.3
      Conserved Domains (3) summary
      PLN03158
      Location:33 → 394
      PLN03158; methionine aminopeptidase; Provisional
      cd01086
      Location:154 → 391
      MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
      pfam15801
      Location:31 → 72
      zf-C6H2; zf-MYND-like zinc finger, mRNA-binding

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      12606821..12633241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017358739.2 → XP_017214228.2  methionine aminopeptidase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q4QRK0, Q6DHD3
      UniProtKB/TrEMBL
      A0A8M6Z3T1
      Conserved Domains (1) summary
      cl00279
      Location:14 → 383
      APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...

    2. XM_021480570.1 → XP_021336245.1  methionine aminopeptidase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9QND6
      Conserved Domains (1) summary
      cl00279
      Location:23 → 285
      APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...

    3. XM_017358740.2 → XP_017214229.1  methionine aminopeptidase 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M6Z9K3

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394870.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      45887..72226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4QRK0.2 GenPept UniProtKB/Swiss-Prot:Q4QRK0

    Gene LinkOut

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