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    FLT1 fms related receptor tyrosine kinase 1 [ Bos taurus (cattle) ]

    Gene ID: 503620, updated on 5-Mar-2024

    Summary

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    Official Symbol
    FLT1provided by VGNC
    Official Full Name
    fms related receptor tyrosine kinase 1provided by VGNC
    Primary source
    VGNC:VGNC:29041
    See related
    BGD:BT12183; Ensembl:ENSBTAG00000016915
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    VEGFR1
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 12
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 12 NC_037339.1 (31624080..31829381)

    Chromosome 12 - NC_037339.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104973568 Neighboring gene uncharacterized LOC132346762 Neighboring gene microRNA mir-2300a Neighboring gene microRNA mir-2300b Neighboring gene poly(A) specific ribonuclease subunit PAN3 Neighboring gene centromere-associated protein E-like Neighboring gene fms related receptor tyrosine kinase 3 Neighboring gene microRNA mir-2285o-2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037339.1 Chromosome 12 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. VEGF receptor-1 involvement in pericyte loss induced by Escherichia coli in an in vitro model of blood brain barrier. Salmeri M, et al. Cell Microbiol, 2013 Aug. PMID 23421875
    2. Vascular Endothelial Growth Factor A and VEGFR-1 Change during Preimplantation in Heifers. Chiumia D, et al. Int J Mol Sci, 2020 Jan 15. PMID 31952188, Free PMC Article
    3. Polymorphisms of RDH16 and VEGFR1 influence M. trapezius steatosis in Japanese Black carcass. Ishida T, et al. Anim Sci J, 2017 Aug. PMID 27878895
    4. Reduction in the mRNA expression of sVEGFR1 and sVEGFR2 is associated with the selection of dominant follicle in cows. Ortega Serrano PV, et al. Reprod Domest Anim, 2016 Dec. PMID 27650571
    5. γ-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1. Cai J, et al. J Biol Chem, 2011 Dec 9. PMID 22016384, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Vascular Endothelial Growth Factor A and VEGFR-1 Change during Preimplantation in Heifers.
      Title: Vascular Endothelial Growth Factor A and VEGFR-1 Change during Preimplantation in Heifers.
    2. Evidence of an altered expression of VEGFA-164, VEGFA-164b and VEGFR2 during the formation of persistent follicles and cysts in cows.
      Title: Contribution of the VEGF system to the follicular persistence associated with bovine cystic ovaries.
    3. There is a possibility that steatosis can be suppressed by the CC genotype in VEGFR1.
      Title: Polymorphisms of RDH16 and VEGFR1 influence M. trapezius steatosis in Japanese Black carcass.
    4. These results suggest that non-dominant follicles maintain a greater concentration of the mRNA expression of both membrane and soluble VEGF receptors; but follicular dominance is related to a reduction in the mRNA expression of sVEGFR1 and sVEGFR2.
      Title: Reduction in the mRNA expression of sVEGFR1 and sVEGFR2 is associated with the selection of dominant follicle in cows.
    5. VEGFR-1 negatively regulates primary bovine retinal pericytes survival, and its blockade protects the blood-brain barrier integrity.
      Title: VEGF receptor-1 involvement in pericyte loss induced by Escherichia coli in an in vitro model of blood brain barrier.
    6. The changes of sVEGFR-1 and sVEGFR-2 with the age of the bovine dominant follicle indicate a physiological role in its growth and atresia.
      Title: Identification of soluble forms of vascular endothelial growth factor receptors, sVEGFR-1 and sVEGFR-2, in bovine dominant follicles.
    7. gamma-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1
      Title: γ-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1.
    8. VEGFR1 mRNA expression was lower at estrus and at the early I and early II luteal stages than at the other stages, whereas VEGFR1 protein expression did not change significantly throughout the estrous cycle (P<0.05)
      Title: Expression of VEGF and its receptors in the bovine endometrium throughout the estrous cycle: effects of VEGF on prostaglandin production in endometrial cells.
    9. Alterations in the expression of VEGF-A and bFGF systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
      Title: Somatic cell nuclear transfer is associated with altered expression of angiogenic factor systems in bovine placentomes at term.
    10. inhibition of VEGFR-1 results in decrease in number of capillary connections indicating VEGFR-1 ligands promote branching angiogenesis.
      Title: Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables vascular endothelial growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vascular endothelial growth factor receptor 1
    Names
    VEGF-receptor
    flt-receptor
    fms related tyrosine kinase 1
    soluble VEGF receptor 1
    vascular endothelial growth factor 1
    vascular endothelial growth factor/vascular permeability factor receptor
    NP_001178061.2
    XP_015329239.1
    XP_024855553.1
    XP_024855554.1
    XP_059747951.1
    XP_059747952.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191132.4 → NP_001178061.2  vascular endothelial growth factor receptor 1 precursor

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000012
      UniProtKB/TrEMBL
      F1MDD9
      Related
      ENSBTAP00000085372.1, ENSBTAT00000092917.1
      Conserved Domains (5) summary
      smart00410
      Location:570 → 641
      IG_like; Immunoglobulin like
      pfam07679
      Location:662 → 749
      I-set; Immunoglobulin I-set domain
      pfam13927
      Location:436 → 540
      Ig_3; Immunoglobulin domain
      cl11960
      Location:354 → 425
      Ig; Immunoglobulin domain
      cl21453
      Location:820 → 1158
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037339.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      31624080..31829381
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015473753.2 → XP_015329239.1  vascular endothelial growth factor receptor 1 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1MF20
      Related
      ENSBTAP00000069115.2, ENSBTAT00000086632.2
      Conserved Domains (4) summary
      smart00408
      Location:700 → 771
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:368 → 459
      IG_like; Immunoglobulin like
      pfam13895
      Location:277 → 354
      Ig_2; Immunoglobulin domain
      cl11960
      Location:484 → 555
      Ig; Immunoglobulin domain

    2. XM_024999786.2 → XP_024855554.1  vascular endothelial growth factor receptor 1 isoform X5

      UniProtKB/TrEMBL
      A0A3Q1MF20
      Related
      ENSBTAP00000080764.1, ENSBTAT00000122860.1
      Conserved Domains (4) summary
      smart00410
      Location:700 → 771
      IG_like; Immunoglobulin like
      pfam13927
      Location:558 → 670
      Ig_3; Immunoglobulin domain
      cl11960
      Location:484 → 555
      Ig; Immunoglobulin domain
      cl28434
      Location:792 → 836
      I-set; Immunoglobulin I-set domain

    3. XM_024999785.2 → XP_024855553.1  vascular endothelial growth factor receptor 1 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1MF20
      Related
      ENSBTAP00000102214.1, ENSBTAT00000100301.1
      Conserved Domains (4) summary
      smart00410
      Location:700 → 771
      IG_like; Immunoglobulin like
      pfam13927
      Location:558 → 670
      Ig_3; Immunoglobulin domain
      cl11960
      Location:484 → 555
      Ig; Immunoglobulin domain
      cl28434
      Location:792 → 836
      I-set; Immunoglobulin I-set domain

    4. XM_059891969.1 → XP_059747952.1  vascular endothelial growth factor receptor 1 isoform X2

      Related
      ENSBTAP00000077891.1, ENSBTAT00000089792.1

    5. XM_059891968.1 → XP_059747951.1  vascular endothelial growth factor receptor 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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